MeDIP Sequencing and Analysis Test
Short Name: MeDIP Seq
Also known as: Methylated DNA Immunoprecipitation Sequencing, MeDIP-seq
MeDIP Sequencing and Analysis Test test available at DNA Labs India for ₹32,000. Uses MeDIP-seq, Next-Generation Sequencing on Extracted DNA samples. Results in Results are typically available within 8 weeks after the sample is received by the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of MeDIP sequencing is to detect and quantify DNA methylation patterns across the genome. This information helps in identifying epigenetic alterations associated with diseases, discovering potential biomarkers for early diagnosis, and guiding personalized treatment strategies. It is also used in research to understand gene regulation mechanisms.
- Test Code
- 6359
- CPT Code
- Not applicable
- ICD Code
- Not applicable
- Price
- ₹32,000
- Sample Type
- Extracted DNA
- Result Time
- Results are typically available within 8 weeks after the sample is received by the laboratory.
- Fasting Required
- No
- Method
- MeDIP-seq, Next-Generation Sequencing
Sample Collection
No special preparation is required. If providing a blood sample, no fasting is needed. Ensure to inform your doctor about any medications or supplements you are taking.
Method: Blood draw or saliva collection (if DNA not already extracted)
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. If you are providing extracted DNA, follow the instructions provided by the laboratory.
Report Delivery
No specific aftercare is required. You can resume normal activities immediately.
Timeline: Results are typically available within 8 weeks after the sample is received by the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of MeDIP sequencing is to detect and quantify DNA methylation patterns across the genome. This information helps in identifying epigenetic alterations associated with diseases, discovering potential biomarkers for early diagnosis, and guiding personalized treatment strategies. It is also used in research to understand gene regulation mechanisms.
How to Prepare
- If blood sample: collect in EDTA tube, mix gently
- If extracted DNA: ensure DNA is in a sterile tube with proper labeling
- Transport samples at room temperature if delivered within 24 hours, otherwise refrigerate
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"MeDIP sequencing provides a genome-wide view of DNA methylation, which is crucial for understanding gene regulation in complex diseases. This test can guide personalized therapeutic decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Insufficient DNA quantity (<500 ng)
- DNA with A260/A280 ratio <1.8 or >2.0
- Sample not labeled correctly
Understanding Your Results
Hypermethylation of tumor suppressor gene promoters
May indicate increased cancer risk or poor prognosis; potential target for demethylating agents
Hypomethylation of oncogene promoters
May lead to overexpression of oncogenes; associated with cancer progression
Differential methylation in neurological disorder-associated genes
May serve as biomarker for early diagnosis or disease progression
Methylation changes in immune-related genes
May contribute to autoimmune pathogenesis; potential for targeted immunotherapy
Consult your doctor if you have been diagnosed with cancer, neurological, or autoimmune disease and are considering epigenetic testing. Also, if you have a family history of these conditions and wish to assess your risk, discuss with your physician.
Limitations
- ⚠MeDIP-seq provides relative methylation levels, not absolute quantification
- ⚠Requires high-quality DNA; degraded samples may yield unreliable results
- ⚠Interpretation may be complex and requires expert analysis
- ⚠Not a diagnostic test for all diseases; results should be correlated with clinical findings
- ⚠May not detect all types of methylation (e.g., non-CpG methylation)
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●No significant risks associated with the test itself
Interfering Factors
- ●Poor quality or degraded DNA
- ●Insufficient DNA quantity
- ●Contamination with RNA or proteins
- ●Recent blood transfusion (if using blood sample)
- ●Chemotherapy or radiation therapy may alter methylation patterns
Compare With Similar Tests
| Test | MeDIP Sequencing and Analysis | Bisulfite Sequencing | Methylation-Specific PCR (MSP) | Pyrosequencing |
|---|---|---|---|---|
| Comparison | MeDIP Sequencing and Analysis |
Frequently Asked Questions
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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