MGP Gene Keutel syndrome NGS Genetic Test
Short Name: MGP Gene Keutel Syndrome NGS
Also known as: Keutel Syndrome NGS Panel, MGP Gene Sequencing, Matrix Gla Protein Gene Test
MGP Gene Keutel syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks from the date of sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to confirm a clinical diagnosis of Keutel syndrome by identifying pathogenic mutations in the MGP gene. It aids in differentiating Keutel syndrome from other conditions with similar features, enables carrier testing for family members, and provides essential information for genetic counseling and reproductive planning. The test also helps in understanding the disease prognosis and guiding surveillance for associated complications such as hearing loss and respiratory issues.
- Test Code
- 5811
- CPT Code
- 81406
- ICD Code
- Q78.8
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks from the date of sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting required. Please provide clinical history and any prior genetic test results. A genetic counseling session will be arranged to draw a pedigree chart.
Method: Venipuncture or Finger-prick
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. For FTA card, a simple finger-prick is sufficient.
Report Delivery
No special precautions. You may resume normal activities immediately.
Timeline: Reports are typically available within 3 to 4 weeks from the date of sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to confirm a clinical diagnosis of Keutel syndrome by identifying pathogenic mutations in the MGP gene. It aids in differentiating Keutel syndrome from other conditions with similar features, enables carrier testing for family members, and provides essential information for genetic counseling and reproductive planning. The test also helps in understanding the disease prognosis and guiding surveillance for associated complications such as hearing loss and respiratory issues.
How to Prepare
- For blood: Use EDTA vacutainer, fill to indicated mark, mix gently
- For FTA card: Apply one drop of blood onto each circle, air dry for 30 minutes
- Label sample with patient name, date, and unique ID
- Transport at ambient temperature (15-30°C) within 24 hours
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Keutel syndrome is a rare autosomal recessive disorder. Early genetic confirmation is crucial for management of respiratory and hearing complications."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improper labeling or missing requisition form
- Sample received after prolonged transit without proper storage
Understanding Your Results
Pathogenic variant detected (homozygous or compound heterozygous)
Confirms diagnosis of Keutel syndrome. Autosomal recessive inheritance. Genetic counseling recommended for family planning.
Single pathogenic variant detected (heterozygous)
Carrier status. Individual is unaffected but at risk of having affected offspring if partner is also a carrier.
No pathogenic variants detected
No evidence of MGP-related Keutel syndrome. Consider other genetic causes or alternative diagnoses.
Variant of uncertain significance (VUS)
Insufficient evidence to classify. Additional testing of family members may help clarify pathogenicity.
Consult a clinical geneticist or pediatrician if your child shows symptoms such as abnormal cartilage calcification, recurrent respiratory infections, hearing loss, or developmental delay. Genetic testing is recommended for early diagnosis and management.
Limitations
- ⚠NGS may not detect large deletions/duplications or deep intronic variants
- ⚠Variants of uncertain significance (VUS) may require further analysis
- ⚠Test does not assess non-coding regulatory regions
- ⚠Negative result does not exclude all genetic causes of similar phenotype
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of receiving a genetic diagnosis
- ●Potential for uncertain results (VUS) requiring further testing
Interfering Factors
- ●Poor DNA quality from degraded samples
- ●Contamination during sample collection
- ●Recent blood transfusion (within 2 weeks) may dilute DNA
- ●Incomplete clinical information may affect interpretation
Compare With Similar Tests
| Test | MGP Gene Keutel syndrome NGS Genetic Test | Sanger Sequencing | Whole Exome Sequencing (WES) | Chromosomal Microarray (CMA) |
|---|---|---|---|---|
| Comparison | MGP Gene Keutel syndrome NGS Genetic Test |
Frequently Asked Questions
What is Keutel Syndrome?
How is Keutel Syndrome inherited?
What does the NGS genetic test for MGP gene detect?
What is the cost of the MGP gene NGS test at DNA Labs India?
What sample is required for the test?
Is fasting required before the test?
How long does it take to get the test results?
Can the test be done at home?
What is the significance of genetic counseling before the test?
What if the test result is negative?
Are there any risks associated with the test?
Is the test covered by insurance?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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