MSRB3 Gene Deafness, autosomal recessive type 74 NGS Genetic Test
Short Name: MSRB3 Gene Deafness NGS Test
Also known as: DFNB74 Deafness, MSRB3-Related Hearing Loss
MSRB3 Gene Deafness, autosomal recessive type 74 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the MSRB3 Gene Deafness NGS Genetic Test is to detect pathogenic mutations in the MSRB3 gene, enabling accurate diagnosis of autosomal recessive deafness type 74. This facilitates early intervention, family risk assessment, and informed reproductive decisions.
- Test Code
- 4744
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. Inform the healthcare provider about any medications or recent medical procedures.
Method: Venipuncture or blood drop
Laboratory Analysis
A trained phlebotomist will collect a blood sample via venipuncture or a blood drop on an FTA card.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Avoid strenuous activity for a few hours.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the MSRB3 Gene Deafness NGS Genetic Test is to detect pathogenic mutations in the MSRB3 gene, enabling accurate diagnosis of autosomal recessive deafness type 74. This facilitates early intervention, family risk assessment, and informed reproductive decisions.
How to Prepare
- Avoid eating or drinking for 30 minutes before blood draw if specified
- Ensure proper identification and labeling of the sample
- Inform about any allergies or bleeding disorders
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for early diagnosis and management of genetic deafness in families, aiding in informed reproductive decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled or contaminated samples
Understanding Your Results
Positive
Pathogenic variant detected, indicating a diagnosis of MSRB3-related deafness and risk for hearing loss.
Negative
No pathogenic variants detected, reducing the likelihood of MSRB3-related deafness.
Variant of Uncertain Significance
A genetic variant was found, but its clinical significance is unknown; further testing or family studies may be needed.
Consult a doctor if you have a family history of deafness, experience symptoms like hearing loss or tinnitus, or receive a positive test result for genetic counseling and management options.
Limitations
- ⚠May not detect all possible mutations in the MSRB3 gene
- ⚠Results require interpretation by a genetic counselor
- ⚠Cannot predict severity or progression of hearing loss
- ⚠Limited to known pathogenic variants in databases
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Psychological impact of genetic results, including anxiety or stress
- ●Potential for uncertain results requiring further investigation
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
- ●Recent blood transfusion
- ●Use of certain medications affecting DNA integrity
Compare With Similar Tests
| Test | MSRB3 Gene Deafness, autosomal recessive type 74 NGS Genetic Test | GJB2 Gene Deafness Test | SLC26A4 Gene Test | OTOF Gene Test | TMC1 Gene Test |
|---|---|---|---|---|---|
| Comparison | MSRB3 Gene Deafness, autosomal recessive type 74 NGS Genetic Test | Targets a different gene commonly associated with non-syndromic hearing loss. | Detects mutations linked to Pendred syndrome and enlarged vestibular aqueduct. | Identifies mutations causing auditory neuropathy spectrum disorder. | Screens for mutations in another gene associated with autosomal recessive deafness. |
Frequently Asked Questions
What is MSRB3 Gene Deafness?
What are the symptoms of MSRB3 Gene Deafness?
How is MSRB3 Gene Deafness diagnosed?
What is the cost of the NGS Genetic Test for MSRB3 Gene Deafness in India?
Is the test covered by insurance?
What sample types are accepted for the test?
How long does it take to get results?
Is home sample collection available?
What should I do if I test positive?
Can this test be used for prenatal diagnosis?
Are there any risks associated with the test?
How accurate is the NGS Genetic Test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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