MT-TS1 Gene MERRF/MELAS overlap syndrome, MT-TS1 related NGS Genetic Test
MT-TS1 Gene MERRF/MELAS overlap syndrome, MT-TS1 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To diagnose MT-TS1 gene mutations causing MERRF/MELAS overlap syndrome, confirm clinical suspicion, identify carriers, and guide management and genetic counseling.
- Test Code
- 2539
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Clinical history of patient and genetic counseling session to draw a pedigree chart of affected family members.
Method: Venipuncture
Laboratory Analysis
Blood sample collected via venipuncture or use of FTA card for one drop of blood.
Report Delivery
Sample transported to laboratory for NGS analysis; report generated in 3-4 weeks.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
To diagnose MT-TS1 gene mutations causing MERRF/MELAS overlap syndrome, confirm clinical suspicion, identify carriers, and guide management and genetic counseling.
How to Prepare
- Avoid hemolysis during blood draw
- Properly label sample with patient details
- Use sterile collection tubes
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for diagnosing mitochondrial disorders, guiding treatment, and informing family planning through genetic counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Contaminated or degraded sample
- Incorrect labeling
Understanding Your Results
If symptoms such as seizures, muscle weakness, or stroke-like episodes occur, or if genetic test results are positive, consult a neurologist or geneticist for management.
Limitations
- ⚠May not detect all genetic variants
- ⚠Requires genetic counseling for interpretation
- ⚠Results may not predict disease severity
Risks & Considerations
- ●Minimal risk from blood draw (bruising, infection)
- ●Potential psychological impact of genetic results
- ●Risk of genetic discrimination
Interfering Factors
- ●Sample contamination
- ●Degraded DNA
- ●Hemolyzed blood sample
Frequently Asked Questions
What is MT-TS1 Gene MERRF/MELAS Overlap Syndrome?
What are the common symptoms of this syndrome?
How is the MT-TS1 Gene NGS Genetic Test performed?
What is the cost of the test in India?
Is home sample collection available for this test?
How long does it take to receive the test results?
What does a positive test result mean?
Is genetic counseling necessary before and after the test?
Are there any risks associated with the genetic test?
Can insurance cover the cost of this test?
What other tests might be needed alongside this genetic test?
How accurate is the NGS Genetic Test for MT-TS1 mutations?
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