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MVK Gene Porokeratosis type 3, disseminated superficial actinic NGS Genetic Test

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MVK Gene Porokeratosis type 3, disseminated superficial actinic NGS Genetic Test

Short Name: MVK Gene Porokeratosis NGS Test

Also known as: Disseminated Superficial Actinic Porokeratosis, DSAP, Porokeratosis type 3

MVK Gene Porokeratosis type 3, disseminated superficial actinic NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to confirm the diagnosis of DSAP by identifying mutations in the MVK gene, guide treatment decisions, and assist in genetic counseling and family planning.

Test Code
5114
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Inform the healthcare provider about any medications or supplements.

Method: Venipuncture for blood, or saliva collection

Step 2

Laboratory Analysis

A small blood sample will be drawn from a vein in your arm, or a saliva sample will be collected.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor or dermatologist to discuss the test and its implications.
2
During the Test:The test involves laboratory analysis of the DNA sample using NGS technology.
3
After the Test:Results will be provided in 3-4 weeks. Follow up with your healthcare provider for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to confirm the diagnosis of DSAP by identifying mutations in the MVK gene, guide treatment decisions, and assist in genetic counseling and family planning.

How to Prepare

  • Stay hydrated
  • Avoid strenuous activity before sample collection
  • Follow instructions for saliva collection if applicable

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for DSAP can aid in family planning and personalized treatment approaches."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per requirement
ContainerEDTA tube for blood
Collection MethodVenipuncture for blood, or saliva collection

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Contaminated sample
  • Incorrect sample type

Understanding Your Results

Results from the MVK Gene Porokeratosis NGS Genetic Test should be interpreted by a qualified geneticist or healthcare provider.
📊

Positive for pathogenic variant

Confirms diagnosis of DSAP due to MVK gene mutation. Genetic counseling recommended.

📊

Negative for pathogenic variant

No MVK gene mutation detected. Clinical correlation advised.

📊

Variant of uncertain significance

Further testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you have symptoms of DSAP, family history of porokeratosis, or after receiving test results for proper management.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Variants of uncertain significance may be identified
  • ⚠Does not replace clinical diagnosis

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestMVK Gene Porokeratosis type 3, disseminated superficial actinic NGS Genetic TestSkin BiopsySanger Sequencing
ComparisonMVK Gene Porokeratosis type 3, disseminated superficial actinic NGS Genetic Test

Frequently Asked Questions

What is MVK Gene Porokeratosis Type 3 DSAP?
It is a subtype of porokeratosis, a rare skin disorder, caused by mutations in the MVK gene, characterized by ring-like skin lesions.
What are the symptoms of DSAP?
Symptoms include small, flat, ring-like lesions with elevated borders, often on forearms, hands, and legs, which may be itchy or tender.
How is DSAP diagnosed?
Diagnosis is based on clinical examination, skin biopsy showing cornoid lamella, and genetic testing to confirm MVK gene mutations.
What is the NGS Genetic Test for MVK Gene?
It is a next-generation sequencing test that analyzes the entire MVK gene to identify mutations associated with DSAP.
What sample is required for the test?
A small blood sample or saliva sample is required. Blood can be drawn via venipuncture or collected on an FTA card.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What are the benefits of genetic testing for DSAP?
Benefits include confirmed diagnosis, identification of specific mutations, guidance for treatment, and assistance in genetic counseling and family planning.
Is the test painful?
The test involves a blood draw, which may cause minor discomfort, but it is generally not painful. Saliva collection is non-invasive.
Can the test be done at home?
Yes, DNA Labs India offers free home sample collection for this test across India.
What is the cost of the test?
The test costs INR 20,000, with free home sample collection included.
Is genetic testing covered by insurance?
Coverage depends on your insurance plan. It is advisable to check with your provider. DNA Labs India offers various payment options.
What should I do if I test positive?
If you test positive, consult a geneticist or dermatologist for further evaluation, management, and genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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