Neuronal (Paraneoplastic) Autoantibodies Profile Ultra Test
Short Name: Paraneoplastic Ab Profile Ultra
Also known as: Paraneoplastic Antibody Panel Ultra, Neuronal Autoantibody Profile, PNS Antibody Panel, Paraneoplastic Neurological Antibody Screen
Neuronal (Paraneoplastic) Autoantibodies Profile Ultra Test test available at DNA Labs India for ₹17,500. Uses Immunoblot on Serum samples. Results in Same day (if sample reaches laboratory by 9 AM, Monday through Saturday). Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect specific neuronal autoantibodies in serum that are associated with paraneoplastic neurological syndromes. It aids in the identification and classification of PNS, guides the search for underlying malignancies (lung, breast, ovarian cancer, thymoma, Hodgkin lymphoma), and supports clinical decision-making regarding oncological treatment and immunotherapy.
- Test Code
- 1297
- CPT Code
- 83516
- ICD Code
- G13.1
- Price
- ₹17,500
- Sample Type
- Serum
- Result Time
- Same day (if sample reaches laboratory by 9 AM, Monday through Saturday)
- Fasting Required
- No
- Method
- Immunoblot
Sample Collection
No special preparation or fasting is required. Inform the phlebotomist about any current immunosuppressive medications or IVIg therapy.
Method: Venipuncture
Laboratory Analysis
A standard venipuncture will be performed. Approximately 2 mL of blood will be drawn into a Serum Separator Tube (SST).
Report Delivery
Apply pressure to the venipuncture site for 3–5 minutes. Mild bruising may occur and resolves on its own. Resume normal activities immediately.
Timeline: Same day (if sample reaches laboratory by 9 AM, Monday through Saturday)
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect specific neuronal autoantibodies in serum that are associated with paraneoplastic neurological syndromes. It aids in the identification and classification of PNS, guides the search for underlying malignancies (lung, breast, ovarian cancer, thymoma, Hodgkin lymphoma), and supports clinical decision-making regarding oncological treatment and immunotherapy.
How to Prepare
- No fasting or special dietary restriction is needed
- Sample: 2 mL (1 mL minimum) serum from 1 SST
- Ship the sample refrigerated (2–8°C) or frozen (−20°C)
- Sample must reach the laboratory by 9 AM for same-day reporting
- Haemolysed or improperly stored samples will be rejected and re-collection requested
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Paraneoplastic neurological syndromes often precede the clinical detection of an underlying malignancy. Early identification of neuronal autoantibodies can guide the search for occult cancers — particularly small-cell lung carcinoma, breast cancer, ovarian tumors, thymoma, and Hodgkin lymphoma. This ultra panel enables simultaneous detection of 12 clinically significant antibodies, supporting timely diagnosis and treatment initiation. A positive result should always be correlated with clinical findings, neuroimaging, and cancer screening. Antibody-negative patients with classic paraneoplastic features should still be evaluated further; seronegative cases are well-documented."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed, lipaemic, or contaminated samples
- Plasma samples instead of serum
- Samples in expired or incompatible containers
- Samples with insufficient volume (< 1 mL serum)
- Samples stored beyond stability window at any temperature
Understanding Your Results
Suggests paraneoplastic encephalomyelitis or subacute sensory neuropathy. Strongly associated with small-cell lung cancer. Immediate lung cancer screening is recommended.
Suggests paraneoplastic cerebellar degeneration. Associated with ovarian or breast cancer. Gynaecological and breast cancer evaluation is warranted.
Suggests opsoclonus-myoclonus syndrome or cerebellar ataxia. Associated with breast cancer or small-cell lung cancer.
Suggests stiff-person syndrome or encephalomyelitis. Associated with breast cancer and small-cell lung cancer.
Suggests peripheral neuropathy, uveitis, or chorea. Associated with small-cell lung cancer and thymoma.
Suggests limbic or brainstem encephalitis. Associated with testicular germ cell tumours.
Suggests paraneoplastic cerebellar degeneration. Associated with Hodgkin lymphoma.
May indicate stiff-person syndrome or cerebellar ataxia. Can also be elevated in type 1 diabetes. Clinical correlation is essential.
Does not exclude paraneoplastic neurological syndrome. Clinical suspicion should guide further evaluation and follow-up.
Consult your neurologist or oncologist immediately if you experience unexplained progressive neurological symptoms such as muscle weakness, loss of coordination, difficulty speaking or swallowing, vision problems, seizures, mental confusion, or unexplained weight loss — especially if you have a known or suspected cancer. A positive autoantibody result requires clinical correlation and further cancer evaluation.
Limitations
- ⚠A negative result does not exclude paraneoplastic neurological syndrome; some cases remain seronegative
- ⚠Antibody detection does not confirm malignancy on its own — clinical correlation and imaging are essential
- ⚠Titres may not correlate directly with disease severity or activity
- ⚠Rare antibodies not included in this panel may require additional or alternative testing
- ⚠This test detects antibody presence and does not quantify titre levels
Risks & Considerations
- ●Minor bruising or discomfort at the venipuncture site
- ●Rare: slight risk of infection at the puncture site
- ●Rare: lightheadedness or fainting during blood draw
Interfering Factors
- ●Immunosuppressive therapy or corticosteroid use may reduce antibody titres and produce false-negative results
- ●Plasma samples (instead of serum) may produce unreliable results
- ●Haemolysed, lipaemic, or contaminated samples can interfere with immunoblot interpretation
- ●Prior intravenous immunoglobulin (IVIg) therapy may cause transient interference
Compare With Similar Tests
| Test | Neuronal (Paraneoplastic) Autoantibodies Profile Ultra Test | ||||
|---|---|---|---|---|---|
| Comparison | Neuronal (Paraneoplastic) Autoantibodies Profile Ultra Test | ANA Profile detects antinuclear antibodies associated with systemic autoimmune diseases (lupus, scleroderma). The Neuronal Autoantibodies Profile specifically targets neuronal antigens linked to paraneoplastic neurological syndromes. | Anti-NMDA receptor antibody testing detects antibodies against cell-surface neuronal targets in autoimmune encephalitis. The PNS Ultra panel focuses on intracellular antigens associated with classic paraneoplastic syndromes and cancer. | AQP4 antibody testing is specific for neuromyelitis optica spectrum disorder (NMOSD). The PNS panel covers a broader set of autoantibodies linked to cancer-associated neurological syndromes. | The MG panel detects anti-AChR and anti-MuSK antibodies specific to myasthenia gravis. The PNS Ultra panel includes SOX1 and Titin antibodies that overlap with MG evaluation in paraneoplastic contexts. |
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