NGSMito Comprehensive NGS Genetic Test
Short Name: NGSMito
Also known as: NGS Mito Test, Full Mitochondrial Genome Sequencing, mtDNA NGS Panel
NGSMito Comprehensive NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood / Extracted DNA / FTA Card samples. Results in Reports are generally delivered in 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of NGSMito Comprehensive NGS Genetic Test is to identify disease-causing variants in the mitochondrial genome. It supports clinicians in diagnosing or excluding mtDNA-related disease across neurological, muscular, cardiac, visual, hearing, and metabolic presentations. The test may also help with family counseling when a pathogenic mitochondrial DNA variant is identified.
- Test Code
- 3850
- Price
- ₹20,000
- Sample Type
- Blood / Extracted DNA / FTA Card
- Result Time
- Reports are generally delivered in 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counseling session is recommended to draw a pedigree chart of family members affected with the condition. Please carry relevant clinical records, imaging, biochemical, and previous genetic testing reports.
Method: Venipuncture, dried blood spot on FTA card, or extracted DNA submission
Laboratory Analysis
A trained phlebotomist will collect venous blood into an EDTA tube or prepare a dried blood spot on an FTA card. If you are submitting extracted DNA, follow the laboratory's sample submission instructions.
Report Delivery
The sample is transported to the laboratory under appropriate conditions. Reports are usually available in 3 to 4 weeks. Please contact your treating doctor for clinical interpretation.
Timeline: Reports are generally delivered in 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of NGSMito Comprehensive NGS Genetic Test is to identify disease-causing variants in the mitochondrial genome. It supports clinicians in diagnosing or excluding mtDNA-related disease across neurological, muscular, cardiac, visual, hearing, and metabolic presentations. The test may also help with family counseling when a pathogenic mitochondrial DNA variant is identified.
How to Prepare
- No fasting is required
- A prior genetic counseling session is recommended to record the family history
- Provide the clinical history and any previous genetic or metabolic test records
- Ensure the sample is correctly labeled with patient name and unique identification number
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A three-generation family pedigree and detailed clinical phenotyping are essential before mitochondrial genome testing. Results should be interpreted by a clinical geneticist or neurologist, and reproductive implications should be discussed with a specialist."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed blood sample
- Insufficient DNA quantity or quality
- Incorrectly labeled sample or incomplete requisition form
- Leaking or broken sample container
- Unapproved sample type or expired collection tube
Understanding Your Results
Pathogenic variant detected
Indicates a molecular alteration known to cause a mitochondrial disorder; clinical correlation and management planning are required.
Likely pathogenic variant detected
Suggests a strong possibility of disease association; additional clinical or family data may support the diagnosis.
Variant of uncertain significance
A genetic alteration was found, but its medical significance is not yet determined; family studies may help clarify its role.
No pathogenic variant detected
Reduces the likelihood of a mtDNA-related mitochondrial disorder but does not exclude all mitochondrial diseases.
Consult your doctor if you or your child have unexplained developmental delay, muscle weakness, seizures, stroke-like episodes, vision or hearing loss, cardiomyopathy, unexplained diabetes, liver disease, or a family history of mitochondrial disease.
Limitations
- ⚠Only mitochondrial DNA variants are detected; nuclear mitochondrial genes are not analyzed
- ⚠A negative result cannot exclude mitochondrial disease caused by nuclear gene variants or other mechanisms
- ⚠This test does not measure mitochondrial DNA copy number or depletion
- ⚠Variants of uncertain significance may require family studies and further clinical correlation
Risks & Considerations
- ●Minor bruising or discomfort at the venipuncture site
- ●Dizziness or fainting during blood collection
- ●FTA card collection is minimally invasive
- ●Genetic results may cause anxiety; genetic counseling is recommended
Interfering Factors
- ●Low DNA quantity or fragmented DNA
- ●Sample contamination during collection or extraction
- ●Heteroplasmic variants present below the assay detection limit
- ●Presence of nuclear mitochondrial DNA segments that may complicate interpretation
- ●Incomplete clinical or family history
Compare With Similar Tests
| Test | NGSMito Comprehensive NGS Genetic Test | NGSMito Comprehensive NGS Genetic Test | Targeted Mitochondrial Mutation Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | NGSMito Comprehensive NGS Genetic Test |
Frequently Asked Questions
What is NGSMito Comprehensive NGS Genetic Test?
How much does NGSMito Comprehensive NGS Genetic Test cost at DNA Labs India?
What sample is required for this test?
Is fasting required before the test?
What conditions can this test help diagnose?
How is the mitochondrial DNA analyzed?
How long will the report take?
Can a negative result rule out mitochondrial disease?
Does the report include interpretation by a doctor?
Will raw data files be provided?
Can NGSMito test detect nuclear gene mitochondrial disorders?
Who should order this test?
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