NGSMito Genome NGS Genetic Test
Short Name: NGSMito Genome
Also known as: NGSMito Genome, Mitochondrial Genome NGS, mtDNA NGS Genetic Test, NGS Mitochondrial Genome Analysis
NGSMito Genome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) – Full Mitochondrial Genome Sequencing on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in 3 to 4 weeks after sample receipt at DNA Labs India. In cases where repeat testing or orthogonal confirmation is required, the turnaround time may be longer.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the NGSMito Genome NGS Genetic Test is to identify mtDNA variants that may cause mitochondrial disorders. The test provides the treating clinician with high-quality sequencing data to support a diagnosis, guide symptomatic management, assess family risk, and inform reproductive planning where appropriate.
- Test Code
- 3853
- CPT Code
- Not available
- ICD Code
- Not available
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- 3 to 4 weeks after sample receipt at DNA Labs India. In cases where repeat testing or orthogonal confirmation is required, the turnaround time may be longer.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS) – Full Mitochondrial Genome Sequencing
Sample Collection
No fasting is required. A genetic counselling session is recommended to document the family history and prepare a pedigree chart. The treating physician should provide the clinical history, relevant biochemical findings, and a list of affected family members if available.
Method: Peripheral blood draw or FTA card blood spot
Laboratory Analysis
A small blood sample is drawn from a vein in the arm by a trained phlebotomist. If the FTA card method is used, a single drop of blood is applied to the card. The process is quick and causes minimal discomfort.
Report Delivery
Once the sample is collected, you may leave immediately and carry on your normal activities. The laboratory will process the sample for NGS analysis. Reports are delivered in 3 to 4 weeks.
Timeline: 3 to 4 weeks after sample receipt at DNA Labs India. In cases where repeat testing or orthogonal confirmation is required, the turnaround time may be longer.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the NGSMito Genome NGS Genetic Test is to identify mtDNA variants that may cause mitochondrial disorders. The test provides the treating clinician with high-quality sequencing data to support a diagnosis, guide symptomatic management, assess family risk, and inform reproductive planning where appropriate.
How to Prepare
- No fasting is required.
- Please carry the doctor's prescription and clinical summary, if available.
- A genetic counselling session will be arranged before sample collection to note family history.
- Verify the sample label and requisition form before giving the sample.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A positive mitochondrial DNA finding can have important implications for the patient and maternal relatives. This test should ideally be ordered after a specialist clinical assessment, and the result should be reviewed with the reporting geneticist as well as the treating physician."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted, severely haemolyzed or contaminated blood sample
- Unlabeled or mislabeled specimen
- Insufficient DNA concentration or degraded DNA
- Improperly stored or expired FTA card
Understanding Your Results
Pathogenic variant detected
Indicates a molecular cause for a mitochondrial disorder. Clinical correlation and maternal family history review are recommended.
Likely pathogenic variant detected
Variant may be disease-causing; additional clinical or family evidence may be required.
Variant of uncertain significance (VUS)
Cannot be definitively classified at this time. Additional family testing or functional studies may be helpful.
No pathogenic variant detected
A mitochondrial genome cause is less likely, but nuclear mitochondrial disorders or low-level heteroplasmy should still be considered.
Consult a doctor if you or your child have unexplained fatigue, muscle weakness, seizures, developmental delay or regression, sensorineural hearing loss, optic atrophy, recurrent vomiting, or metabolic acidosis. These symptoms need a comprehensive medical evaluation before any genetic testing is considered.
Limitations
- ⚠This test evaluates only the mitochondrial genome and not nuclear genes involved in mitochondrial function.
- ⚠Very low heteroplasmy or certain structural rearrangements may not be detected by standard NGS.
- ⚠A negative result does not exclude mitochondrial disease; clinical correlation and additional biochemical or nuclear gene testing may be needed.
- ⚠Variant classification may change as scientific knowledge evolves.
Risks & Considerations
- ●Minor bruising at the puncture site
- ●Dizziness or light-headedness during or after blood draw
- ●Very small risk of local infection if the site is not kept clean
Interfering Factors
- ●Low heteroplasmy below the validated detection threshold
- ●Clotted, haemolyzed or degraded DNA sample
- ●Contamination by nuclear-mitochondrial DNA segments (NUMTs) requiring bioinformatics filtering
- ●Recent allogeneic stem cell transplant or blood transfusion may affect blood-derived DNA results; notify the laboratory prior to testing
Compare With Similar Tests
| Test | NGSMito Genome NGS Genetic Test | NGSMito Genome NGS | NGSMito Genome NGS | NGSMito Genome NGS |
|---|---|---|---|---|
| Comparison | NGSMito Genome NGS Genetic Test |
Frequently Asked Questions
What is the NGSMito Genome NGS Genetic Test?
What is the cost of the NGSMito Genome NGS Genetic Test?
Is fasting required for this test?
What sample is needed for the NGSMito Genome test?
How long does it take to get the report?
Will I receive raw data with my report?
What symptoms suggest a mitochondrial DNA disorder?
Is the NGSMito Genome test covered by health insurance?
Can this test detect all mitochondrial disorders?
Who should request this test?
Does a negative result exclude mitochondrial disease?
How should I prepare for the test?
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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