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Noonan - RASophathies Panel NGS Genetic Test

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Noonan - RASophathies Panel NGS Genetic Test

Short Name: Noonan RAS Panel NGS

Also known as: Noonan Syndrome Panel, RASopathy Genetic Test, RAS-MAPK Pathway Panel

Noonan - RASophathies Panel NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Pediatrics🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify genetic mutations associated with Noonan syndrome and related RASopathies for diagnostic, prognostic, and counseling purposes, enabling personalized medical management.

Test Code
5640
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide detailed clinical history and family pedigree during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected by a trained phlebotomist using standard venipuncture techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities unless advised otherwise.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a healthcare provider to determine if genetic testing is appropriate based on symptoms and family history.
2
During the Test:The test involves DNA extraction and sequencing using NGS technology to analyze the specified gene panel.
3
After the Test:Results will be provided along with a genetic counseling session to discuss findings and implications.

About This Test

Who Should Get This Test

To identify genetic mutations associated with Noonan syndrome and related RASopathies for diagnostic, prognostic, and counseling purposes, enabling personalized medical management.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Label samples accurately with patient details
  • Follow sample handling guidelines

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for RASopathies is crucial for timely intervention, management of symptoms, and informed family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable at room temperature for up to 24 hours
Extracted DNA stable for extended periods when stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or clotted samples
  • Improperly labeled or contaminated samples

Understanding Your Results

Results from the Noonan - RASophathies Panel NGS Genetic Test should be interpreted by a qualified geneticist or healthcare provider in the context of clinical findings.
Positive result: Pathogenic variant detected, indicating a diagnosis of a RASopathy such as Noonan syndrome
Negative result: No pathogenic variants detected, but clinical correlation is essential as symptoms may be due to other causes
Variant of uncertain significance: Further testing, family studies, or clinical follow-up may be required for clarification
⚠️ When to Consult a Doctor:

If symptoms suggestive of RASopathies persist, if there is a family history of genetic disorders, or if results indicate a positive or uncertain finding, consult a geneticist or pediatrician for further evaluation and management.

Limitations

  • ⚠May not detect all genetic variants or mutations
  • ⚠Variants of uncertain significance may be identified
  • ⚠Does not rule out other genetic conditions or syndromes

Risks & Considerations

  • ●Minimal risk associated with blood draw, such as bruising or infection at the puncture site
  • ●Psychological impact of genetic results, addressed through counseling

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestNoonan - RASophathies Panel NGS Genetic TestWhole Exome SequencingSingle Gene TestingCardiac Genetic PanelDevelopmental Delay Panel
ComparisonNoonan - RASophathies Panel NGS Genetic Test

Frequently Asked Questions

What is Noonan syndrome?
Noonan syndrome is a genetic disorder that affects various parts of the body, characterized by short stature, heart defects, distinctive facial features, and other health issues.
What are RASopathies?
RASopathies are a group of genetic conditions caused by mutations in the RAS-MAPK pathway, including Noonan syndrome, Costello syndrome, and others.
How is the Noonan RAS Panel NGS Genetic Test performed?
The test uses Next-Generation Sequencing (NGS) to analyze DNA from a blood sample for mutations in genes associated with RASopathies.
What genes are analyzed in this test?
The panel includes genes such as BRAF, CBL, HRAS, KRAS, PTPN11, RAF1, SOS1, and others linked to Noonan syndrome and related disorders.
Who should consider taking this test?
Individuals with symptoms like short stature, heart defects, learning difficulties, or a family history of RASopathies should consider genetic testing.
What is the cost of the Noonan RAS Panel NGS Genetic Test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results mean?
Results indicate whether pathogenic variants are detected. A positive result suggests a RASopathy diagnosis, while negative or uncertain results require clinical correlation.
Is genetic counseling included with the test?
Yes, a genetic counseling session is included to discuss results, implications, and family planning.
Can this test be used for prenatal diagnosis?
This test is primarily for postnatal diagnosis. For prenatal testing, consult a genetic specialist for appropriate options.
What are the risks associated with the test?
The risks are minimal, primarily related to blood draw, such as bruising. Psychological support is available through counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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