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NR3C1 Gene Glucocorticoid resistance, generalized NGS Genetic Test

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NR3C1 Gene Glucocorticoid resistance, generalized NGS Genetic Test

Short Name: NR3C1 Glucocorticoid Resistance Test

Also known as: NR3C1 Gene Test, Glucocorticoid Resistance Genetic Test, NR3C1 Mutation Analysis

NR3C1 Gene Glucocorticoid resistance, generalized NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the NR3C1 gene that cause glucocorticoid resistance, aiding in diagnosis, treatment planning, and genetic counseling for affected individuals and families.

Test Code
5400
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree chart during genetic counseling.

Method: Venipuncture or Blood drop

Step 2

Laboratory Analysis

A small blood sample is collected via venipuncture or a blood drop on an FTA card by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Store sample as per instructions for stability.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss symptoms, family history, and test implications.
2
During the Test:Blood sample collection and analysis using NGS technology.
3
After the Test:Review results with a genetic counselor and plan follow-up care.

About This Test

Who Should Get This Test

To identify mutations in the NR3C1 gene that cause glucocorticoid resistance, aiding in diagnosis, treatment planning, and genetic counseling for affected individuals and families.

How to Prepare

  • Ensure proper identification of patient
  • Use sterile equipment
  • Label sample correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for diagnosing rare genetic disorders affecting stress response and inflammation, guiding personalized treatment plans."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or Blood drop

Sample Stability

Blood sample stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or storage

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the NR3C1 gene. Positive results confirm glucocorticoid resistance, while negative results may require further clinical evaluation.
📊

Positive for pathogenic variant

Confirms diagnosis of glucocorticoid resistance; genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected; consider other causes of symptoms.

📊

Variant of uncertain significance

Further testing and clinical correlation needed.

⚠️ When to Consult a Doctor:

Consult a genetic counselor or endocrinologist if symptoms persist, for family planning, or to understand test results and management options.

Limitations

  • ⚠May not detect all possible mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical symptoms

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare infection risk
  • ●Emotional impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestNR3C1 Gene Glucocorticoid resistance, generalized NGS Genetic TestACTH Stimulation TestCortisol Level TestCYP21A2 Gene TestWhole Exome Sequencing
ComparisonNR3C1 Gene Glucocorticoid resistance, generalized NGS Genetic TestMeasures adrenal function but does not identify genetic mutations.Assesses cortisol levels but cannot diagnose genetic resistance.Tests for congenital adrenal hyperplasia, a different endocrine disorder.Broader genetic test but more expensive and time-consuming.

Frequently Asked Questions

What is the NR3C1 Gene Glucocorticoid Resistance Test?
It is an NGS genetic test that detects mutations in the NR3C1 gene causing glucocorticoid resistance, a rare disorder affecting stress response.
How much does the test cost?
The test costs INR 20000 at DNA Labs India, with home sample collection available.
What are the symptoms of glucocorticoid resistance?
Symptoms include chronic fatigue, low blood pressure, frequent infections, and difficulty gaining weight.
How is the test performed?
A blood sample is collected and analyzed using Next-Generation Sequencing to identify genetic mutations.
Is fasting required for the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
Is home sample collection available?
Yes, DNA Labs India offers free home collection across many cities in India.
What does a positive result mean?
A positive result confirms a genetic mutation causing glucocorticoid resistance, guiding treatment and counseling.
Can the test be done on children?
Yes, the test is suitable for all ages, but genetic counseling is recommended.
What should I do before the test?
Provide clinical history and undergo genetic counseling to draw a family pedigree chart.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw, with no significant health risks.
How accurate is the test?
The test uses advanced NGS technology, making it highly accurate and reliable for detecting mutations.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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