Skip to main content
DNA Labs India

NRAS Gene Noonan syndrome type 6 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NRAS Gene Noonan syndrome type 6 NGS Genetic Test

Short Name: NRAS NGS Test

Also known as: NRAS Gene Mutation Test, Noonan Syndrome Type 6 Genetic Test, NRAS Sequencing

NRAS Gene Noonan syndrome type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to confirm or rule out a diagnosis of Noonan syndrome type 6 in individuals presenting with characteristic clinical features or a family history of the condition. It also helps in genetic counseling, reproductive planning, and guiding personalized management strategies.

Test Code
5873
CPT Code
81407
ICD Code
Q87.19
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. However, a genetic counseling session is recommended before the test to discuss the implications and obtain informed consent.

Method: Venipuncture or Fingerstick

Step 2

Laboratory Analysis

A blood sample will be drawn by a trained phlebotomist. If using FTA card, a simple fingerstick is performed. The procedure is quick and minimally invasive.

Step 3

Report Delivery

No specific aftercare is needed. You can resume normal activities immediately. The sample will be sent to the laboratory for analysis.

Timeline: Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Before the test, you will have a genetic counseling session to discuss the purpose, risks, benefits, and potential outcomes. A pedigree chart will be drawn to assess family history.
2
During the Test:The test involves a simple blood draw or fingerstick. No anesthesia is required. The procedure takes about 5 minutes.
3
After the Test:After the sample is collected, it is sent to the laboratory. You will receive the report in 3-4 weeks. A genetic counselor will explain the results and their implications.

About This Test

Who Should Get This Test

The purpose of this test is to confirm or rule out a diagnosis of Noonan syndrome type 6 in individuals presenting with characteristic clinical features or a family history of the condition. It also helps in genetic counseling, reproductive planning, and guiding personalized management strategies.

How to Prepare

  • For blood sample: Use EDTA vacutainer, fill to the indicated mark, and mix gently.
  • For FTA card: Apply one drop of blood onto the designated circle, allow to air dry for at least 30 minutes.
  • Label the sample with patient's name, date of birth, and collection date.
  • Transport the sample at ambient temperature to the laboratory within 24 hours.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Noonan syndrome type 6 is a rare RASopathy. Early genetic confirmation is crucial for management of cardiac, growth, and developmental issues. NGS provides comprehensive analysis of the NRAS gene and related panel."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume2-3 ml blood or 1 drop on FTA card
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or Fingerstick

Sample Stability

Blood in EDTA: 24 hours at room temperature, 7 days at 2-8°C
FTA card: Stable for months at room temperature
Extracted DNA: Stable for years at -20°C
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Improper labeling
  • Sample received after prolonged transit time without proper storage

Understanding Your Results

The test report will indicate whether a pathogenic variant in the NRAS gene was identified. If a pathogenic variant is found, it confirms the diagnosis of Noonan syndrome type 6. If no variant is found, it does not completely rule out the condition, as other genes may be involved.
📊

Pathogenic variant detected

Diagnosis of Noonan syndrome type 6 is confirmed. Genetic counseling and family screening are recommended.

📊

Likely pathogenic variant detected

Highly suggestive of the condition; further evidence may be needed but clinical correlation is advised.

📊

Variant of uncertain significance (VUS)

The clinical significance is unclear. Additional testing or family studies may help clarify.

📊

No pathogenic variant detected

No mutation in NRAS gene was found. Other genetic causes should be considered.

⚠️ When to Consult a Doctor:

If you or your child experience symptoms suggestive of Noonan syndrome, such as short stature, characteristic facial features, heart defects, or developmental delays, consult a clinical geneticist or pediatrician for evaluation. Early diagnosis can significantly improve outcomes.

Limitations

  • ⚠This test detects mutations in the NRAS gene only; other genes associated with Noonan syndrome are not analyzed unless included in a panel.
  • ⚠Variants of uncertain significance (VUS) may be reported; further testing or family studies may be needed.
  • ⚠Large deletions/duplications may not be detected by standard NGS; additional methods may be required.
  • ⚠Regulatory regions and deep intronic variants are not covered.
  • ⚠Results should be interpreted in the context of clinical findings and family history.

Risks & Considerations

  • ●Minimal risk of bruising or infection at the blood draw site
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results (VUS)

Interfering Factors

  • ●Poor DNA quality or quantity
  • ●Contamination during sample collection
  • ●Recent blood transfusion (within 2 weeks)
  • ●Bone marrow transplantation (may affect results)

Compare With Similar Tests

TestNRAS Gene Noonan syndrome type 6 NGS Genetic TestNoonan Syndrome Panel (Multiple Genes)Sanger Sequencing for NRASChromosomal Microarray
ComparisonNRAS Gene Noonan syndrome type 6 NGS Genetic Test

Frequently Asked Questions

What is Noonan syndrome type 6?
Noonan syndrome type 6 is a genetic disorder caused by mutations in the NRAS gene. It is characterized by short stature, distinctive facial features, heart defects, and developmental delays.
How is this test performed?
The test uses Next-Generation Sequencing (NGS) to analyze the NRAS gene. A blood sample or FTA card sample is collected and sent to the laboratory.
What is the cost of the test?
The test costs INR 20,000, which includes genetic counseling and free home sample collection.
How long does it take to get results?
Reports are typically available within 3 to 4 weeks after the sample is received.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Can this test be done on children?
Yes, the test can be performed on individuals of any age, including infants and children.
What does a positive result mean?
A positive result indicates the presence of a pathogenic variant in the NRAS gene, confirming the diagnosis of Noonan syndrome type 6.
What if the result is negative?
A negative result means no mutation was found in the NRAS gene. However, other genetic causes may still be possible, and further testing may be recommended.
Is genetic counseling included?
Yes, a genetic counseling session is included before and after the test to help you understand the implications.
Can I get a home sample collection?
Yes, we offer free home sample collection in many cities across India. Please check availability for your location.
What is the sample type required?
The sample can be blood (2-3 ml in EDTA tube) or one drop of blood on an FTA card.
Are there any risks associated with the test?
The test is safe with minimal risks, such as slight bruising at the blood draw site. There may be psychological impact from the results, which is why counseling is provided.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

MSX2 Gene Craniosynostosis type 2 NGS Genetic Test

₹20,000

EVC2 Gene Ellis-van Creveld syndrome NGS Genetic Test

₹20,000

FGFR2 Gene Saethre-Chotzen syndrome NGS Genetic Test

₹20,000

TSPYL1 Gene Sudden infant death with dysgenesis of the testes syndrome NGS Genetic Test

₹20,000

ATRX Gene Alpha-thalassemia/mental retardation syndrome NGS Genetic Test

₹20,000

PTH1R Gene Chondrodysplasia, Blomstrand type NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.