OTOA Gene Deafness, autosomal recessive type 22 NGS Genetic Test
Short Name: OTOA Genetic Test
Also known as: DFNB22, OTOA-related hearing loss
OTOA Gene Deafness, autosomal recessive type 22 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify mutations in the OTOA gene associated with autosomal recessive deafness type 22 (DFNB22), aiding in accurate diagnosis, genetic counseling, and management of hereditary hearing loss.
- Test Code
- 2327
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks after sample collection.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A genetic counseling session is recommended to discuss clinical history and family pedigree. No specific preparation like fasting is required, but avoid contaminants on the sample collection site.
Method: Venipuncture or FTA card application
Laboratory Analysis
Standard blood draw from a vein using a sterile needle or application of a blood drop on an FTA card, following aseptic techniques.
Report Delivery
The sample is labeled, stored at ambient temperature, and transported to the laboratory for DNA extraction and NGS sequencing.
Timeline: Results are typically available within 3 to 4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
To identify mutations in the OTOA gene associated with autosomal recessive deafness type 22 (DFNB22), aiding in accurate diagnosis, genetic counseling, and management of hereditary hearing loss.
How to Prepare
- Fasting is not required for this test
- Provide detailed clinical and family history during pre-test counseling
- Ensure proper labeling of the sample to avoid mix-ups
- Use the provided collection kit for home sample collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for diagnosing hereditary hearing loss in families, enabling early intervention and genetic counseling for affected individuals."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improperly labeled or contaminated samples
Understanding Your Results
Pathogenic variant detected
Confirms a diagnosis of OTOA gene deafness. Genetic counseling recommended for family planning and management options such as hearing aids or cochlear implants.
No pathogenic variant detected
Unlikely to have OTOA gene deafness; consider other genetic or environmental causes of hearing loss. Further clinical evaluation may be needed.
Variant of uncertain significance
The identified variant's clinical impact is unclear. Additional testing, family studies, or clinical follow-up is advised.
If you experience symptoms of hearing loss, have a family history of deafness, or if genetic testing is recommended by a healthcare provider. Early consultation allows for timely diagnosis and intervention.
Limitations
- ⚠May not detect all types of genetic variants (e.g., large deletions)
- ⚠Results require clinical correlation and genetic counseling
- ⚠Limited to mutations in the OTOA gene; other causes of deafness may not be identified
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or discomfort
- ●Potential psychological impact from genetic diagnosis
- ●Risk of incidental findings or variants of uncertain significance
Interfering Factors
- ●Poor sample quality or contamination
- ●DNA degradation due to improper storage
- ●Technical errors in sequencing
Compare With Similar Tests
| Test | OTOA Gene Deafness, autosomal recessive type 22 NGS Genetic Test | GJB2 Gene Deafness NGS Genetic Test | SLC26A4 Gene Deafness NGS Genetic Test | TMC1 Gene Deafness Genetic Test | Comprehensive Hearing Loss Gene Panel |
|---|---|---|---|---|---|
| Comparison | OTOA Gene Deafness, autosomal recessive type 22 NGS Genetic Test |
Frequently Asked Questions
What is OTOA gene deafness?
How is OTOA gene deafness inherited?
What are the common symptoms of OTOA gene deafness?
How is OTOA gene deafness diagnosed?
What is NGS genetic testing?
What is the cost of the OTOA gene test in India?
Is home sample collection available for this test?
How long does it take to get the test results?
Is the OTOA gene test covered by insurance in India?
Can this test be done during pregnancy?
What should I do if the test is positive for OTOA gene deafness?
Are there any risks associated with genetic testing for deafness?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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