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DNA Labs India

OTOF Gene Deafness, autosomal recessive type 9 NGS Genetic Test

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OTOF Gene Deafness, autosomal recessive type 9 NGS Genetic Test

Short Name: OTOF Gene Deafness Test

Also known as: DFNB9, OTOF-related deafness

OTOF Gene Deafness, autosomal recessive type 9 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the OTOF gene that cause autosomal recessive deafness type 9, aiding in diagnosis, genetic counseling, and family planning.

Test Code
4754
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree if available.

Method: Venipuncture or Saliva collection

Step 2

Laboratory Analysis

A blood sample or saliva sample will be collected by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide detailed clinical and family history. Genetic counseling may be recommended prior to testing.
2
During the Test:Sample collection is quick and non-invasive, typically taking a few minutes.
3
After the Test:Results are delivered online or via email/WhatsApp. Follow-up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the OTOF gene that cause autosomal recessive deafness type 9, aiding in diagnosis, genetic counseling, and family planning.

How to Prepare

  • Ensure sample is collected in a sterile environment
  • Label sample correctly with patient details
  • Transport sample at ambient temperature as specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for early diagnosis and management of hereditary deafness, aiding in genetic counseling and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or Saliva collection

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Incorrect sample labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the OTOF gene. Positive results confirm a genetic basis for deafness, while negative results may require further testing.
📊

Positive for pathogenic variant

Confirms diagnosis of OTOF-related deafness; genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected; consider other genetic or non-genetic causes.

📊

Variant of uncertain significance

Further evaluation and family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a geneticist or ENT specialist if you have a family history of deafness, unexplained hearing loss, or if test results are positive or uncertain.

Limitations

  • ⚠May not detect all possible mutations in the OTOF gene
  • ⚠Results require interpretation by a genetic counselor
  • ⚠Does not rule out other causes of deafness

Risks & Considerations

  • ●Minimal physical risks from blood draw
  • ●Potential psychological impact of results
  • ●Privacy concerns with genetic data

Interfering Factors

  • ●Degraded or contaminated DNA sample
  • ●Insufficient sample volume
  • ●Recent blood transfusion

Compare With Similar Tests

TestOTOF Gene Deafness, autosomal recessive type 9 NGS Genetic TestGJB2 Gene Deafness TestSLC26A4 Gene TestComprehensive Hearing Loss PanelWhole Exome Sequencing
ComparisonOTOF Gene Deafness, autosomal recessive type 9 NGS Genetic Test

Frequently Asked Questions

What is OTOF gene deafness?
OTOF gene deafness is an autosomal recessive condition caused by mutations in the OTOF gene, leading to hearing loss known as DFNB9.
How is the OTOF gene test performed?
The test uses Next-Generation Sequencing (NGS) to analyze DNA from a blood or saliva sample for mutations in the OTOF gene.
What is the cost of the OTOF gene deafness test?
The test costs INR 20,000 at DNA Labs India, which includes home sample collection across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results indicate?
Results show whether pathogenic mutations in the OTOF gene are detected, confirming a genetic cause for deafness.
Is genetic counseling recommended?
Yes, genetic counseling is advised before and after testing to understand implications and family risks.
Can this test be done for children?
Yes, the test is suitable for all ages, including infants and children with hearing concerns.
What if the test result is negative?
A negative result means no OTOF mutations were found; other genetic or environmental factors may be explored.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. DNA Labs India offers transparent pricing without insurance dependency.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted samples for this test.
How accurate is the NGS genetic test?
NGS technology provides high accuracy for detecting mutations, but results should be interpreted by a qualified geneticist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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