PCDH15 Gene Deafness, autosomal recessive type 23 NGS Genetic Test
Short Name: PCDH15 DFNB23 NGS Test
Also known as: DFNB23, PCDH15-Related Deafness
PCDH15 Gene Deafness, autosomal recessive type 23 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify mutations in the PCDH15 gene that cause autosomal recessive deafness type 23, enabling accurate diagnosis, treatment planning, and genetic counseling.
- Test Code
- 2332
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Genetic counseling is recommended prior to testing. Ensure clinical history and family pedigree are documented.
Method: Venipuncture or Blood Drop on FTA Card
Laboratory Analysis
Blood sample collected via venipuncture or a drop on FTA card by trained phlebotomist.
Report Delivery
Sample is transported to the lab under controlled conditions for DNA extraction and analysis.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify mutations in the PCDH15 gene that cause autosomal recessive deafness type 23, enabling accurate diagnosis, treatment planning, and genetic counseling.
How to Prepare
- Bring doctor's prescription and ID proof
- No fasting required
- Ensure sample is properly labeled
- For FTA card, follow provided instructions for blood application
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for PCDH15 mutations can guide treatment, hearing interventions, and family planning for hereditary deafness."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Incorrect labeling or documentation
Understanding Your Results
Positive
Pathogenic or likely pathogenic variant detected in PCDH15 gene, confirming diagnosis of DFNB23.
Action: Consult with a geneticist or ENT specialist for management and family counseling.
Negative
No pathogenic variants detected in PCDH15 gene.
Action: Clinical correlation needed; consider other genetic or non-genetic causes of hearing loss.
Variant of Uncertain Significance (VUS)
Variant detected but clinical significance is unclear.
Action: Repeat testing or additional family studies may be recommended; consult genetic counselor.
If the test result is positive or uncertain, or if hearing loss symptoms persist, consult an ENT specialist or geneticist for further evaluation and management.
Limitations
- ⚠May not detect all types of mutations, such as large deletions or intronic variants
- ⚠Results require interpretation by a genetic counselor or clinician
- ⚠Not suitable for prenatal diagnosis without additional validation
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Genetic information may have psychological or social implications
- ●Risk of inconclusive results requiring further testing
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
- ●Technical errors during sequencing
Compare With Similar Tests
| Test | PCDH15 Gene Deafness, autosomal recessive type 23 NGS Genetic Test | GJB2 Gene Deafness Test | SLC26A4 Gene Deafness Test |
|---|---|---|---|
| Comparison | PCDH15 Gene Deafness, autosomal recessive type 23 NGS Genetic Test |
Frequently Asked Questions
What is PCDH15 Gene Deafness?
How is the NGS Genetic Test performed?
What is the cost of the test in India?
Is home sample collection available?
How long does it take to get results?
What does a positive result mean?
Can this test be used for prenatal diagnosis?
Is genetic counseling required before testing?
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What should I do if the result is negative but hearing loss persists?
Is the test covered by insurance?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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