PIIINP (Procollagen Type III Amino Terminal Propeptide) Test
Short Name: PIIINP Test
Also known as: Procollagen III N-terminal propeptide, PIIINP, Amino-terminal propeptide of type III procollagen
PIIINP (Procollagen Type III Amino Terminal Propeptide) Test test available at DNA Labs India for ₹5,500. Uses CLIA on Serum samples. Results in Reports are available next day after sample submission.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The primary purpose of the PIIINP test is to assess liver fibrosis and early fibrogenesis. It is used to evaluate liver damage in patients with chronic liver disease and to monitor drug-induced hepatotoxicity, particularly from methotrexate therapy. The test aids in identifying high-risk individuals and supports clinical decision-making for further diagnostic workup.
- Test Code
- 3557
- Price
- ₹5,500
- Sample Type
- Serum
- Result Time
- Reports are available next day after sample submission.
- Fasting Required
- Yes (8 hours)
- Method
- CLIA
Sample Collection
Overnight fasting is preferred. Continue regular medications unless advised otherwise by your physician.
Method: Venipuncture
Laboratory Analysis
A blood sample is drawn from a vein in the arm using a sterile needle.
Report Delivery
No special precautions are required; you may resume normal activities immediately.
Timeline: Reports are available next day after sample submission.
About This Test
Who Should Get This Test
The primary purpose of the PIIINP test is to assess liver fibrosis and early fibrogenesis. It is used to evaluate liver damage in patients with chronic liver disease and to monitor drug-induced hepatotoxicity, particularly from methotrexate therapy. The test aids in identifying high-risk individuals and supports clinical decision-making for further diagnostic workup.
How to Prepare
- Overnight fasting (8-10 hours) is preferred for optimal accuracy
- Inform your doctor about any ongoing medications, especially methotrexate
- Wear loose clothing for easy access to the arm
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The PIIINP test is a valuable non-invasive marker for early liver fibrosis and should be interpreted alongside clinical findings and other liver function tests."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or grossly lipemic samples
- Insufficient sample volume
- Incorrectly labeled specimen
- Sample received after prolonged delay without proper storage
Understanding Your Results
No significant active fibrogenesis; low likelihood of ongoing liver fibrosis.
May indicate active liver fibrosis, inflammation, or methotrexate-induced hepatotoxicity. Further evaluation with imaging or biopsy may be required.
Consult your physician if you experience symptoms such as jaundice, abdominal swelling, persistent fatigue, or if you are on methotrexate therapy and require liver monitoring.
Risks & Considerations
- ●Minimal risk of bleeding, bruising, or infection at the puncture site
Interfering Factors
- ●Pregnancy and growth hormone can increase PIIINP levels
- ●Active wound healing or recent surgery may elevate results
- ●Age and gender can affect reference ranges
- ●Severe fibrosis or cirrhosis may not show elevated PIIINP levels due to reduced fibrogenesis
Frequently Asked Questions
What is the PIIINP test?
Why is the PIIINP test done?
What conditions are associated with elevated PIIINP levels?
Is fasting required for the PIIINP blood test?
How is the PIIINP test performed?
What does a high PIIINP level indicate?
Can the PIIINP test be used for methotrexate monitoring?
What is the normal reference range for PIIINP?
How long does it take to get PIIINP test results?
Is home sample collection available for the PIIINP test?
What is the cost of the PIIINP test at DNA Labs India?
Who should consider taking the PIIINP test?
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.