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PITX1 Gene Club foot NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

PITX1 Gene Club foot NGS Genetic Test

Short Name: PITX1 Clubfoot NGS Test

Also known as: Talipes Equinovarus, Clubfoot

PITX1 Gene Club foot NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the PITX1 gene associated with clubfoot, enabling genetic diagnosis, risk assessment, and informed clinical management.

Test Code
5717
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected by trained phlebotomist using standard venipuncture or FTA card method.

Step 3

Report Delivery

Sample labeled and transported to the laboratory for NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling recommended to discuss test implications and family history.
2
During the Test:Sample collection and laboratory analysis using NGS technology.
3
After the Test:Report generation, delivery, and follow-up consultation for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the PITX1 gene associated with clubfoot, enabling genetic diagnosis, risk assessment, and informed clinical management.

How to Prepare

  • Fast if required (though not typically needed)
  • Bring valid ID and prescription
  • Inform about any medications or health conditions
  • Ensure proper sample labeling

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for identifying genetic causes of clubfoot, aiding in early diagnosis, personalized treatment, and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the PITX1 gene, which may be associated with clubfoot risk.
Positive: Pathogenic variant detected, indicating genetic predisposition to clubfoot
Negative: No pathogenic variants detected, reducing genetic risk
Variant of Uncertain Significance (VUS): Further testing or clinical correlation needed
⚠️ When to Consult a Doctor:

If clubfoot symptoms are present, family history exists, or for prenatal counseling and management planning.

Limitations

  • ⚠May not detect all genetic variants or non-genetic causes
  • ⚠Results should be interpreted in conjunction with clinical findings
  • ⚠Limited to PITX1 gene analysis; other genes may be involved

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare infection risk
  • ●Emotional impact of results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestPITX1 Gene Club foot NGS Genetic TestClubfoot Panel NGS TestWhole Exome SequencingChromosomal Microarray Analysis
ComparisonPITX1 Gene Club foot NGS Genetic Test

Frequently Asked Questions

What is the PITX1 Gene Clubfoot NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to analyze the PITX1 gene for mutations associated with clubfoot.
Why is this test important?
It helps identify genetic causes of clubfoot, aiding in diagnosis, treatment planning, and genetic counseling.
Who should get tested?
Individuals with clubfoot symptoms, family history of clubfoot, or prenatal findings suggestive of the condition.
How is the test performed?
A blood or DNA sample is collected and analyzed using NGS technology to detect mutations in the PITX1 gene.
What samples are required?
Blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required for the test?
No, fasting is not typically required for this genetic test.
How long does it take to get results?
Results are available in 3 to 4 weeks after sample collection.
What do the results mean?
Results indicate if pathogenic variants in the PITX1 gene are present, which may increase clubfoot risk.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw; emotional impact of results should be considered.
Is the test covered by insurance?
Coverage varies; check with your insurance provider or schemes like PMJAY, CGHS, etc.
How much does the test cost?
The test costs INR 20000, including home sample collection and genetic counseling.
Where can I get tested?
DNA Labs India offers this test across India with home sample collection in numerous cities; book online or contact for details.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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