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PLCE1 Gene Nephrotic syndrome type 3 NGS Genetic Test

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PLCE1 Gene Nephrotic syndrome type 3 NGS Genetic Test

Short Name: PLCE1 Gene Test

Also known as: PLCE1-related nephrotic syndrome genetic test, Nephrotic Syndrome Type 3 DNA test

PLCE1 Gene Nephrotic syndrome type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic Test is to detect mutations in the PLCE1 gene that cause Nephrotic Syndrome Type 3. This helps in confirming diagnosis, guiding treatment, assessing family risk, and enabling early intervention to manage symptoms and prevent kidney damage.

Test Code
2620
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling.

Method: Venipuncture or blood drop

Step 2

Laboratory Analysis

A blood sample is drawn via venipuncture or a blood drop is collected on an FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling to discuss test implications and family history.
2
During the Test:Sample collection and analysis using NGS technology.
3
After the Test:Report delivery and follow-up counseling to discuss results and management options.

About This Test

Who Should Get This Test

The purpose of the PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic Test is to detect mutations in the PLCE1 gene that cause Nephrotic Syndrome Type 3. This helps in confirming diagnosis, guiding treatment, assessing family risk, and enabling early intervention to manage symptoms and prevent kidney damage.

How to Prepare

  • Ensure proper identification
  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for PLCE1 mutations can aid in timely diagnosis and management of nephrotic syndrome, potentially improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or blood drop

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient volume
  • Improper labeling
  • Contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PLCE1 gene. Positive results confirm genetic predisposition to Nephrotic Syndrome Type 3.
Positive result: Mutation detected, indicating genetic cause for nephrotic syndrome
Negative result: No mutation detected, but clinical symptoms may require further evaluation
Variant of uncertain significance: Requires additional testing and genetic counseling
⚠️ When to Consult a Doctor:

Consult a nephrologist or geneticist immediately if symptoms persist, results are positive, or for family planning advice.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires interpretation by a genetic specialist
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal physical risks from blood draw
  • ●Potential psychological impact of results
  • ●Insurance or discrimination concerns

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Recent blood transfusions

Frequently Asked Questions

What is the PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the PLCE1 gene, which cause Nephrotic Syndrome Type 3, a rare kidney disorder.
Who should consider this test?
Individuals with symptoms like swelling, foamy urine, or a family history of nephrotic syndrome should consider this test for early diagnosis.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with home sample collection available across India.
How is the sample collected?
A blood sample is collected via venipuncture or a blood drop on an FTA card, with home collection options.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results indicate?
Results show if pathogenic mutations in the PLCE1 gene are present, confirming genetic cause for nephrotic syndrome.
Is genetic counseling provided?
Yes, DNA Labs India offers a genetic counseling session to discuss results and implications.
Can this test be done at home?
Yes, home sample collection is available for online bookings in many cities across India.
What are the risks of the test?
Risks are minimal, mainly related to blood draw, but psychological impact of results should be considered.
Is the test covered by insurance?
Coverage depends on your insurance policy; check with your provider for details.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting gene mutations, but results should be interpreted by a genetic specialist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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