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Pre-Implantation Genetic Disorder/PGD HLA Typing (Single Embryo) Test

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Pre-Implantation Genetic Disorder/PGD HLA Typing (Single Embryo) Test

Short Name: PGD HLA Typing

Also known as: PGD HLA Typing, Pre-implantation Genetic Diagnosis HLA Typing, Embryo HLA Typing

Pre-Implantation Genetic Disorder/PGD HLA Typing (Single Embryo) Test test available at DNA Labs India for ₹30,000. Uses Sanger Sequencing on Trophectoderm samples. Results in Results are typically available within 3 weeks after sample collection.. Free home collection in 300+ cities across India.

Gynecological Genetic TestReproductive Age (Adults)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of PGD HLA Typing is to identify genetic abnormalities and determine the HLA type of embryos during IVF, ensuring selection of healthy embryos that are HLA-compatible for siblings needing bone marrow transplants, thereby preventing transmission of genetic disorders and supporting treatment of existing conditions.

Test Code
3164
Price
₹30,000
Sample Type
Trophectoderm
Result Time
Results are typically available within 3 weeks after sample collection.
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

A doctor's prescription is required, except for surgery, pregnancy cases, or individuals planning to travel abroad. Pre-test counseling with a genetic counselor is recommended.

Method: Embryo biopsy (Trophectoderm biopsy)

Step 2

Laboratory Analysis

The collection involves a trophectoderm biopsy performed by a trained embryologist during the IVF process, where a few cells are removed from the embryo for analysis.

Step 3

Report Delivery

Post-biopsy, the embryo is monitored, and patients may experience mild discomfort. Results are typically available in 3 weeks, and follow-up consultation is advised.

Timeline: Results are typically available within 3 weeks after sample collection.

Patient Instructions

1
Before the Test:Genetic counseling, doctor's prescription, and IVF cycle preparation are required before the test.
2
During the Test:Embryo biopsy is performed during the IVF process, typically on day 5 or 6 of embryo development.
3
After the Test:Embryos are vitrified or transferred based on results; patients receive reports and counseling.

About This Test

Who Should Get This Test

The purpose of PGD HLA Typing is to identify genetic abnormalities and determine the HLA type of embryos during IVF, ensuring selection of healthy embryos that are HLA-compatible for siblings needing bone marrow transplants, thereby preventing transmission of genetic disorders and supporting treatment of existing conditions.

How to Prepare

  • Use a cool pack for sample transport if applicable
  • Ensure proper handling by certified personnel
  • Follow clinic-specific protocols for embryo biopsy

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"PGD HLA Typing is a critical tool for couples undergoing IVF with a history of genetic disorders, helping to select healthy embryos and ensure compatibility for potential bone marrow transplants."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTrophectoderm
Collection MethodEmbryo biopsy (Trophectoderm biopsy)

Sample Stability

Sample should be processed immediately after collection
Stability depends on transport conditions; use cool packs as recommended
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated sample
  • Improper labeling or documentation

Understanding Your Results

Results from PGD HLA Typing indicate the genetic status and HLA type of the embryo. A positive result for genetic disorders means the embryo carries mutations, while HLA typing shows compatibility for transplant purposes.
Normal result: No pathogenic mutations detected and HLA type identified
Abnormal result: Genetic mutations present, indicating risk for disorder
HLA match: Embryo is compatible with sibling for bone marrow transplant
Consult a genetic counselor for detailed explanation and next steps
⚠️ When to Consult a Doctor:

Consult your doctor or genetic counselor immediately after receiving results to discuss implications for IVF, family planning, and potential treatment options for affected siblings.

Limitations

  • ⚠Tests only for specific genetic disorders and HLA types
  • ⚠Requires embryo biopsy which may pose minimal risks
  • ⚠Results are based on a single embryo and may not reflect all embryos
  • ⚠False positives or negatives are possible, though rare

Risks & Considerations

  • ●Minimal risk to embryo from biopsy procedure
  • ●Potential for false results, though accuracy is high
  • ●Emotional stress related to genetic outcomes

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during biopsy
  • ●Technical errors in sequencing

Compare With Similar Tests

TestPre-Implantation Genetic Disorder/PGD HLA Typing (Single Embryo)PGT-A (Pre-implantation Genetic Testing for Aneuploidies)PGT-M (Pre-implantation Genetic Testing for Monogenic disorders)Standard HLA TypingCarrier Screening
ComparisonPre-Implantation Genetic Disorder/PGD HLA Typing (Single Embryo)

Frequently Asked Questions

What is PGD HLA Typing?
PGD HLA Typing is a genetic test performed on embryos during IVF to identify genetic disorders and determine the Human Leukocyte Antigen (HLA) type, which is important for bone marrow transplant compatibility.
Why is PGD HLA Typing done?
It is done to select healthy embryos for implantation and ensure HLA compatibility with a sibling who may need a bone marrow transplant due to a genetic disease.
What is the cost of PGD HLA Typing in India?
The cost for a single embryo is INR 30,000 at DNA Labs India, which includes home sample collection services.
How is the test performed?
A biopsy of the trophectoderm layer of the embryo is taken during IVF, and the cells are analyzed using Sanger Sequencing to detect genetic mutations and HLA types.
Is the test painful?
The biopsy procedure is performed on embryos, so there is no pain for the patient. However, the IVF process may involve discomfort.
What are the risks of PGD HLA Typing?
Risks include minimal harm to the embryo from biopsy, potential for false results, and emotional stress. Accuracy is generally high.
How long does it take to get results?
Results are typically available within 3 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
Do I need a doctor's prescription?
Yes, a doctor's prescription is required, except for surgery, pregnancy cases, or individuals planning to travel abroad.
What genetic disorders can be detected?
Common disorders include cystic fibrosis, sickle cell anemia, thalassemia, hemophilia, and Tay-Sachs disease, among others.
How accurate is PGD HLA Typing?
The test is highly accurate due to advanced sequencing methods, but like all genetic tests, there is a small chance of false positives or negatives.
Can PGD HLA Typing be used for gender selection?
No, PGD HLA Typing is specifically for detecting genetic disorders and HLA types, not for gender selection, which may be regulated or unethical in many regions.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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