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PROK2 Gene Kallmann syndrome type 4 NGS Genetic Test

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PROK2 Gene Kallmann syndrome type 4 NGS Genetic Test

Short Name: PROK2 Kallmann Syndrome Type 4 NGS Test

Also known as: Kallmann Syndrome Type 4 Genetic Test, PROK2 Gene Sequencing Test

PROK2 Gene Kallmann syndrome type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the PROK2 gene that cause Kallmann Syndrome Type 4, aiding in diagnosis, genetic counseling, and treatment planning for affected individuals.

Test Code
2608
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling as recommended.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm, or a drop of blood on an FTA card may be used. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities. Store samples as instructed if self-collected.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling to understand the test implications and provide informed consent.
2
During the Test:Sample collection via blood draw or FTA card. The test involves NGS analysis in the laboratory.
3
After the Test:Await results for 3 to 4 weeks. Discuss findings with a genetic counselor or physician for next steps.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the PROK2 gene that cause Kallmann Syndrome Type 4, aiding in diagnosis, genetic counseling, and treatment planning for affected individuals.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment for blood collection
  • Label samples correctly
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for diagnosing Kallmann Syndrome Type 4, guiding hormone therapy and fertility management. Early detection improves patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA Card

Sample Stability

Ambient Room TemperatureStable for several days if properly stored
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the PROK2 gene. Positive results confirm a genetic basis for Kallmann Syndrome Type 4, while negative results may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of Kallmann Syndrome Type 4. Genetic counseling and treatment planning recommended.

📊

No pathogenic variant detected

Kallmann Syndrome Type 4 unlikely due to PROK2 mutations. Consider other genetic or clinical evaluations.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms like absent puberty, infertility, or loss of smell, or if genetic testing results are positive for mutations.

Limitations

  • ⚠May not detect all possible mutations in the PROK2 gene
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Technical errors in sequencing

Compare With Similar Tests

TestPROK2 Gene Kallmann syndrome type 4 NGS Genetic TestKallmann Syndrome Type 1 Genetic TestGnRH Receptor Gene Test
ComparisonPROK2 Gene Kallmann syndrome type 4 NGS Genetic TestTests for mutations in the ANOS1 gene, another cause of Kallmann syndrome.Evaluates genes involved in gonadotropin-releasing hormone signaling.

Frequently Asked Questions

What is Kallmann Syndrome Type 4?
Kallmann Syndrome Type 4 is a rare genetic disorder that affects the development of the olfactory system and reproductive system, leading to reduced sense of smell, delayed puberty, and infertility.
What is the PROK2 gene?
The PROK2 gene produces a protein crucial for olfactory system development and gonadotropin-releasing hormone production. Mutations in this gene cause Kallmann Syndrome Type 4.
How is the PROK2 Gene Kallmann Syndrome Type 4 NGS Genetic Test performed?
The test uses next-generation sequencing (NGS) technology to analyze the PROK2 gene from a blood or DNA sample, identifying mutations associated with the syndrome.
What is the cost of this test?
The test cost is INR 20000, which includes sample collection, analysis, and genetic counseling.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What are the symptoms of Kallmann Syndrome Type 4?
Symptoms include reduced or absent sense of smell, delayed or absent puberty, infertility, abnormal facial features, and hearing loss.
Who should consider this test?
Individuals with symptoms of Kallmann syndrome, a family history of the disorder, or those seeking genetic diagnosis for reproductive planning.
What does a positive result mean?
A positive result confirms a mutation in the PROK2 gene, indicating a genetic cause for Kallmann Syndrome Type 4, which guides treatment and counseling.
Is genetic counseling required?
Yes, genetic counseling is recommended before and after testing to understand implications and interpret results.
Are there any risks associated with the test?
Risks are minimal, primarily related to blood draw, such as bruising. Psychological impacts of results should be discussed with a counselor.
Can this test be used for prenatal diagnosis?
This test is typically for diagnostic purposes in symptomatic individuals. Prenatal testing may require specific consultation with a genetic specialist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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