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PROKR2 Gene Hypogonadotropic hypogonadism type 3 with or without anosmia NGS Genetic Test

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PROKR2 Gene Hypogonadotropic hypogonadism type 3 with or without anosmia NGS Genetic Test

Short Name: PROKR2 Gene HH3 NGS Test

Also known as: HH3 Genetic Test, PROKR2 Mutation Analysis, Hypogonadotropic Hypogonadism Type 3 DNA Test

PROKR2 Gene Hypogonadotropic hypogonadism type 3 with or without anosmia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAdolescents and Adults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose hypogonadotropic hypogonadism type 3 caused by mutations in the PROKR2 gene, enabling accurate identification of the genetic basis for symptoms like delayed puberty and infertility, and guiding personalized medical management.

Test Code
5440
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Step 2

Laboratory Analysis

A blood sample is drawn via venipuncture or a saliva sample is collected using a kit.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising; store samples as instructed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment are recommended before testing.
2
During the Test:Sample collection is quick and minimally invasive, typically taking a few minutes.
3
After the Test:Results are delivered online; follow-up with a healthcare provider is advised for management.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose hypogonadotropic hypogonadism type 3 caused by mutations in the PROKR2 gene, enabling accurate identification of the genetic basis for symptoms like delayed puberty and infertility, and guiding personalized medical management.

How to Prepare

  • Fast for 8-12 hours if required, though not mandatory for this test
  • Use sterile collection tubes for blood samples
  • Label samples correctly with patient details
  • Transport samples at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of HH3 allows for tailored hormone replacement therapy and management of fertility issues, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Incorrectly labeled samples
  • Contaminated samples

Understanding Your Results

Results are interpreted based on the presence or absence of pathogenic variants in the PROKR2 gene. A positive result indicates a genetic cause for HH3, while a negative result may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of HH3; genetic counseling and treatment recommended

📊

No pathogenic variant detected

HH3 due to PROKR2 mutation unlikely; consider other genetic or non-genetic causes

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of delayed puberty, infertility, or decreased sex drive, especially with a family history of hypogonadism or anosmia.

Limitations

  • ⚠May not detect all rare variants in the PROKR2 gene
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings
  • ⚠Does not rule out other genetic causes of hypogonadism

Risks & Considerations

  • ●Minor pain or bruising at the blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Incorrect sample storage
  • ●Recent blood transfusions

Compare With Similar Tests

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ComparisonPROKR2 Gene Hypogonadotropic hypogonadism type 3 with or without anosmia NGS Genetic Test

Frequently Asked Questions

What is the PROKR2 Gene Hypogonadotropic Hypogonadism Type 3 NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the PROKR2 gene, which cause hypogonadotropic hypogonadism type 3, a condition leading to delayed puberty and infertility.
Who should consider this test?
Individuals with symptoms like delayed puberty, infertility, irregular periods, or decreased sex drive, especially if there is a family history of hypogonadism or anosmia.
How is the test performed?
The test requires a blood or saliva sample, which is analyzed using NGS technology to identify variants in the PROKR2 gene.
What is the cost of the test in India?
The test costs INR 20000 at DNA Labs India, with home sample collection available.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
A positive result indicates a pathogenic PROKR2 mutation causing HH3, while a negative result suggests other causes. Genetic counseling is provided for interpretation.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort, but it is generally quick and safe.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What are the risks of the test?
Risks are minimal and include minor bruising at the sample site. There are no significant medical risks.
How accurate is the test?
The test uses advanced NGS technology with high accuracy for detecting PROKR2 gene mutations, but results should be correlated with clinical findings.
What should I do after receiving the results?
Consult a healthcare provider, such as an endocrinologist, to discuss treatment options like hormone replacement therapy based on the results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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