Protein - Creatinine Ratio Urine Test
Short Name: SPEP with Immunotyping
Also known as: Serum Protein Electrophoresis (SPEP) with Immunofixation, Immunotyping Serum Test, Protein Electrophoresis with Immunofixation
Protein - Creatinine Ratio Urine Test test available at DNA Labs India for ₹10,000. Uses Capillary Electrophoresis, Agarose Gel Immunofixation Electrophoresis on Serum samples. Results in Reports are typically available the next working day after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
This test measures total protein and separates protein fractions using densitometric tracing. Immunotyping precisely characterises any abnormal monoclonal protein (M-protein) bands, aiding in the diagnosis and monitoring of conditions such as multiple myeloma, macroglobulinemia, and related plasma cell disorders. It also supports the differentiation between monoclonal and polyclonal gammopathies.
- Test Code
- 3573
- Price
- ₹10,000
- Sample Type
- Serum
- Result Time
- Reports are typically available the next working day after sample collection.
- Fasting Required
- No
- Method
- Capillary Electrophoresis, Agarose Gel Immunofixation Electrophoresis
Sample Collection
No special preparation required. Continue your regular diet and medications unless advised otherwise by your doctor.
Method: Blood draw
Laboratory Analysis
A trained phlebotomist collects about 2 mL of blood from a vein in your arm. The procedure is quick and safe.
Report Delivery
You can return to your normal activities immediately. If you feel dizzy, sit for a few minutes before leaving.
Timeline: Reports are typically available the next working day after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
This test measures total protein and separates protein fractions using densitometric tracing. Immunotyping precisely characterises any abnormal monoclonal protein (M-protein) bands, aiding in the diagnosis and monitoring of conditions such as multiple myeloma, macroglobulinemia, and related plasma cell disorders. It also supports the differentiation between monoclonal and polyclonal gammopathies.
How to Prepare
- No fasting required
- Inform your doctor about any recent infections or vaccinations
- Do not submit grossly hemolyzed samples
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for evaluating monoclonal gammopathies. A monoclonal spike on electrophoresis with immunotyping helps guide further workup for multiple myeloma or related disorders."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Grossly hemolyzed samples are not accepted
Understanding Your Results
Normal pattern
Monoclonal spike (M protein)
Increased polyclonal gamma globulins
Decreased albumin
Seek medical advice if you have persistent bone pain, unexplained fatigue, weight loss, recurrent infections, or abnormal protein levels on routine blood tests.
Limitations
- ⚠Not a definitive diagnostic test alone; requires clinical correlation
- ⚠May not detect very low levels of monoclonal protein
- ⚠Cannot identify the source of abnormal protein; bone marrow biopsy may be needed for definitive diagnosis
- ⚠Reference ranges vary by laboratory and patient age
Risks & Considerations
- ●Minor bruising at the needle site
- ●Slight pain or discomfort during blood draw
- ●Rare risk of infection or prolonged bleeding
Interfering Factors
- ●Gross hemolysis of the sample
- ●Recent infections or acute inflammation
- ●Certain medications (e.g., steroids, anticonvulsants)
- ●Contrast media used in imaging procedures
- ●Improper storage or delayed processing
Frequently Asked Questions
What is the protein electrophoresis and immunotyping serum test?
What conditions can this test detect?
Is fasting required before this test?
How is the sample collected?
How long does it take to get the report?
What does an M protein band mean?
Can this test diagnose multiple myeloma?
What is the difference between protein electrophoresis and immunotyping?
Are there any home collection options?
Is this test covered by health insurance?
What are the symptoms that may require this test?
What is the price of this test?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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