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RGS9BP Gene Bradyopsia NGS Genetic Test

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RGS9BP Gene Bradyopsia NGS Genetic Test

Short Name: RGS9BP Bradyopsia NGS

Also known as: RGS9BP gene mutation analysis, Bradyopsia genetic test, RGS9BP next generation sequencing, R9AP retinopathy genetic panel

RGS9BP Gene Bradyopsia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued within 3 to 4 weeks from sample receipt at the laboratory.. Free home collection in 300+ cities across India.

NGS Gene AnalysisAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the RGS9BP gene that are associated with bradyopsia. It assists in confirming a clinical diagnosis, enabling early management, clarifying recurrence risks, and identifying at-risk family members.

Test Code
3777
CPT Code
81406
ICD Code
H53.8
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are issued within 3 to 4 weeks from sample receipt at the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required before blood collection. No fasting is needed. Please bring any previous vision test reports or family history documentation if available.

Method: Peripheral Blood Collection

Step 2

Laboratory Analysis

A trained phlebotomist will collect blood from a vein in your arm. If you are providing an FTA card sample, a single drop of blood is placed on the card.

Step 3

Report Delivery

You can resume all normal activities immediately after sample collection. There are no restrictions. Mild soreness or bruising at the needle site is possible and resolves quickly.

Timeline: Reports are issued within 3 to 4 weeks from sample receipt at the laboratory.

Patient Instructions

1
Before the Test:No special preparation is required. Inform your doctor about any symptoms, family history of vision disorders, or previous eye surgeries. Provide any available retinal imaging or electrophysiology reports to assist interpretation.
2
During the Test:The test involves a simple blood sample collection. For home collection, the phlebotomist will arrive at your scheduled time and deliver the sample to the laboratory. If you are providing an FTA card, the process is minimally invasive.
3
After the Test:The collected sample is processed in the genetics laboratory. You will receive the clinical report, along with raw NGS data files, within 3 to 4 weeks. A genetic counselor may contact you to discuss results.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the RGS9BP gene that are associated with bradyopsia. It assists in confirming a clinical diagnosis, enabling early management, clarifying recurrence risks, and identifying at-risk family members.

How to Prepare

  • No fasting required.
  • Sample to be collected in an EDTA vacutainer for whole blood.
  • For FTA card, apply one drop of blood onto the labelled circles.
  • Ensure sample is labelled correctly with patient name, date of birth, and collection date.
  • Transport at room temperature for FTA card and refrigerate whole blood if delay is expected.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for inherited retinal disorders like bradyopsia is essential for accurate diagnosis, risk assessment, and family planning decisions. This NGS-based test provides precise information that can guide management and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml Whole Blood or 1-2 µg DNA
ContainerEDTA Vacutainer / FTA Card
Collection MethodPeripheral Blood Collection

Sample Stability

Whole blood in EDTA: 24 hours at 15-25°C, 7 days at 2-8°C
Extracted DNA: 6 months at -20°C
FTA card: stable at room temperature for months if kept dry and sealed
Sample Rejection Criteria:
  • Hemolysed or clotted blood sample
  • Incorrect labelling
  • Improper transport temperature
  • Insufficient sample volume or DNA quantity
  • Sample container broken or leaking during transit

Understanding Your Results

The result is interpreted by a clinical geneticist in the context of the patient's clinical symptoms, family history, and other diagnostic findings. Variant classification follows ACMG guidelines.
Positive: A pathogenic or likely pathogenic variant in RGS9BP confirms the diagnosis of bradyopsia.
Negative: No pathogenic variant detected; however, this does not entirely rule out genetic or non-genetic causes.
Variant of Uncertain Significance (VUS): The variant is not clearly linked to disease; further familial testing may help determine its significance.
Carrier: One heterozygous pathogenic variant indicates carrier status for autosomal recessive bradyopsia.
⚠️ When to Consult a Doctor:

Consult an ophthalmologist or clinical geneticist if you experience symptoms like delayed dark adaptation, light sensitivity, or unexplained visual impairment, particularly if there is a family history of inherited retinal disease.

Limitations

  • ⚠This test only analyzes the RGS9BP gene and does not assess other genes associated with inherited retinal disorders
  • ⚠Large deletions, duplications, and deep intronic variants may not be detected by standard NGS
  • ⚠A negative result does not exclude a non-genetic cause or a variant in another gene
  • ⚠Variants of uncertain clinical significance may be reported and require further segregation analysis

Risks & Considerations

  • ●No significant invasive risks are associated with a blood draw.
  • ●Mild pain, bruising, or small hematoma may occur at the puncture site.
  • ●Rarely, patients may feel dizzy or lightheaded during the blood draw.

Interfering Factors

  • ●No specific dietary restrictions required
  • ●Very low DNA concentration or degraded DNA may affect NGS results
  • ●Variants in regulatory regions may not be detected by this NGS assay
  • ●Contamination of sample can cause false results

Compare With Similar Tests

TestRGS9BP Gene Bradyopsia NGS Genetic TestRGS9BP Gene Bradyopsia NGS Genetic TestHereditary Retinal Dystrophy NGS PanelWhole Exome Sequencing
ComparisonRGS9BP Gene Bradyopsia NGS Genetic Test

Frequently Asked Questions

What is the RGS9BP Gene Bradyopsia NGS Genetic Test?
It is a next-generation sequencing test that analyzes the RGS9BP gene to identify mutations associated with bradyopsia, a rare inherited retinal disorder affecting light adaptation.
What is the cost of the RGS9BP Gene Bradyopsia NGS Genetic Test at DNA Labs India?
The test costs INR 20,000. This includes home sample collection, NGS analysis, clinical report, and raw data files.
What is bradyopsia?
Bradyopsia is a rare genetic eye condition where patients have difficulty adapting to changes in light, particularly delayed recovery of vision after bright light exposure and difficulty seeing in low light.
What symptoms are associated with RGS9BP gene mutations?
Common symptoms include sensitivity to bright light, delayed dark adaptation, difficulty in low-light environments, and in some cases, reduced visual acuity.
What type of sample is required for this test?
A blood sample in an EDTA vacutainer, extracted DNA, or one drop of blood on an FTA card is accepted.
Do I need to fast for this genetic test?
No, fasting is not required for the RGS9BP Gene Bradyopsia NGS Genetic Test.
How long does it take to get results?
The turnaround time is 3 to 4 weeks from the time the sample is received at the lab.
Will I receive raw data files with the report?
Yes, DNA Labs India provides raw NGS data files (FASTQ, VCF) along with the clinical report for full transparency.
Is home sample collection available?
Yes, free home sample collection is available across major cities in India for online bookings.
Can this test be used for prenatal diagnosis?
Prenatal genetic testing is a separate service. This test is intended for diagnostic confirmation and carrier screening. Consult your genetic counselor for prenatal testing options.
Who should consider taking this test?
Individuals with symptoms of bradyopsia, those with a family history of inherited retinal disorders, or persons seeking carrier screening for RGS9BP mutations should consider this test.
What does a negative test result mean?
A negative result suggests no pathogenic variants were detected in the RGS9BP gene. However, it does not rule out other genetic or non-genetic causes of visual symptoms.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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