ROMA Risk of Ovarian Malignancy Algorithm Test
Short Name: ROMA
Also known as: ROMA Test, Risk of Ovarian Malignancy Algorithm, HE4 + CA125 Risk Assessment
ROMA Risk of Ovarian Malignancy Algorithm Test test available at DNA Labs India for ₹4,500. Uses Chemiluminescent Microparticle Immunoassay on Serum from SST samples. Results in Samples received by 4 pm on Monday or Thursday are processed and reports are released the same day. Please confirm current scheduling at the time of booking.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To help assess whether a woman with a pelvic mass is at low or high risk for ovarian malignancy, based on HE4, CA125 and menopausal status. ROMA is not a diagnostic test and must be used with clinical and radiological assessment.
- Test Code
- 3613
- Price
- ₹4,500
- Sample Type
- Serum from SST
- Result Time
- Samples received by 4 pm on Monday or Thursday are processed and reports are released the same day. Please confirm current scheduling at the time of booking.
- Fasting Required
- No
- Method
- Chemiluminescent Microparticle Immunoassay
Sample Collection
No fasting is required. Please provide your menopausal status, current symptoms and relevant medical history to the requesting doctor.
Method: Venipuncture
Laboratory Analysis
A single blood sample of 2 mL will be collected from a vein in your arm using a sterile technique. The process is quick and usually takes less than 5 minutes.
Report Delivery
You may resume normal activities immediately. If mild bruising occurs at the puncture site, it usually resolves on its own.
Timeline: Samples received by 4 pm on Monday or Thursday are processed and reports are released the same day. Please confirm current scheduling at the time of booking.
Patient Instructions
About This Test
Who Should Get This Test
To help assess whether a woman with a pelvic mass is at low or high risk for ovarian malignancy, based on HE4, CA125 and menopausal status. ROMA is not a diagnostic test and must be used with clinical and radiological assessment.
How to Prepare
- Collect 2 mL venous blood in a Serum Separator Tube (SST).
- Allow the sample to clot before centrifugation.
- Separate serum and ship refrigerated or frozen.
- Menopausal status is mandatory on the requisition form.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The ROMA test should be requested by a physician when there is clinical or radiological suspicion of an ovarian mass. It helps in risk stratification but does not replace tissue diagnosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Specimen without mentioning menopausal status
- Severely haemolysed or lipaemic sample
- Improper storage or delayed transport after separation
Understanding Your Results
Premenopausal < 11.4%
Low risk category for ovarian malignancy
Premenopausal ≥ 11.4%
High risk category for ovarian malignancy; further evaluation recommended
Postmenopausal < 29.9%
Low risk category for ovarian malignancy
Postmenopausal ≥ 29.9%
High risk category for ovarian malignancy; further evaluation recommended
Consult a doctor if you have persistent abdominal bloating, pelvic or abdominal pain, difficulty eating, feeling full quickly, urinary urgency or frequency, or unexplained weight loss. Early evaluation may help in detecting ovarian cancer at an earlier stage.
Limitations
- ⚠ROMA is an aid in risk assessment, not a diagnostic test.
- ⚠It is not intended for ovarian cancer screening in asymptomatic women.
- ⚠It does not detect all types of ovarian cancers, including non-epithelial or borderline tumours.
- ⚠A low ROMA score does not completely exclude malignancy.
- ⚠Results should be interpreted with clinical examination, imaging and, where required, tissue biopsy.
Risks & Considerations
- ●Mild pain or discomfort at the needle site
- ●Slight bruising
- ●Dizziness or lightheadedness
- ●Rare risk of infection or bleeding
Interfering Factors
- ●CA125 can be elevated in endometriosis, menstruation, pregnancy, pelvic inflammatory disease, uterine fibroids and benign ovarian cysts.
- ●HE4 levels may be affected by renal impairment.
- ●Incorrect or missing menopausal status can affect ROMA interpretation.
- ●Recent surgery, peritonitis or pleural effusion may elevate CA125.
Compare With Similar Tests
| Test | ROMA Risk of Ovarian Malignancy Algorithm Test | |||
|---|---|---|---|---|
| Comparison | ROMA Risk of Ovarian Malignancy Algorithm Test |
Frequently Asked Questions
What is ROMA Risk of Ovarian Malignancy Algorithm test?
Is fasting required for the ROMA test?
Which tumour markers are measured in the ROMA test?
How is the ROMA score interpreted?
What is the cost of the ROMA test at DNA Labs India?
Is home sample collection available for the ROMA test?
Who should take the ROMA test?
Can a positive ROMA test diagnose ovarian cancer?
What is the sample type required for the ROMA test?
When will I get the ROMA test report?
What is HE4 in the ROMA test?
What is CA125 in the ROMA test?
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