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RPL21 Gene Hypotrichosis type 12 NGS Genetic Test

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RPL21 Gene Hypotrichosis type 12 NGS Genetic Test

Short Name: RPL21 Hypotrichosis NGS Test

Also known as: RPL21-related hypotrichosis, Type 12 hypotrichosis, Autosomal dominant hypotrichosis 12

RPL21 Gene Hypotrichosis type 12 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the RPL21 Gene Hypotrichosis Type 12 NGS Genetic Test is to detect mutations in the RPL21 gene that cause Hypotrichosis Type 12, enabling accurate diagnosis, genetic counseling, and assessment of inheritance risks for affected individuals and their families.

Test Code
4981
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history of the patient and undergo a genetic counseling session to draw a pedigree chart of family members affected with hypotrichosis.

Method: Venipuncture or FTA card

Step 2

Laboratory Analysis

Sample collection via venipuncture or using an FTA card for blood drop.

Step 3

Report Delivery

Sample is processed for NGS analysis; results are reviewed by geneticists.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended before testing.
2
During the Test:Sample collection is a simple blood draw or FTA card procedure.
3
After the Test:Results are available in 3-4 weeks; follow-up counseling is advised.

About This Test

Who Should Get This Test

The purpose of the RPL21 Gene Hypotrichosis Type 12 NGS Genetic Test is to detect mutations in the RPL21 gene that cause Hypotrichosis Type 12, enabling accurate diagnosis, genetic counseling, and assessment of inheritance risks for affected individuals and their families.

How to Prepare

  • Collect blood sample in EDTA tube or use FTA card for one drop of blood.
  • Ensure proper labeling and handling of the sample.
  • Transport sample at ambient room temperature.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for hypotrichosis can aid in family planning and early diagnosis, especially for autosomal dominant conditions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA card

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the RPL21 gene. A positive result confirms Hypotrichosis Type 12, while a negative result may require further testing or clinical evaluation.
📊

Positive for RPL21 mutation

Confirms diagnosis of Hypotrichosis Type 12. Genetic counseling recommended for family risk assessment.

📊

Negative for RPL21 mutation

No mutation detected in the RPL21 gene. Consider other genetic or environmental causes; clinical correlation advised.

⚠️ When to Consult a Doctor:

Consult a doctor or genetic counselor if you or a family member experience symptoms such as sparse hair growth, thin brittle hair, or absent eyebrows/eyelashes, especially with a family history of similar conditions.

Limitations

  • ⚠Test may not detect all possible mutations in the RPL21 gene.
  • ⚠Results require interpretation by a genetic specialist.
  • ⚠Does not assess other genetic or non-genetic causes of hypotrichosis.

Risks & Considerations

  • ●Minimal risks associated with blood draw, such as bruising or infection.
  • ●Psychological impact of genetic diagnosis.

Frequently Asked Questions

What is Hypotrichosis Type 12?
Hypotrichosis Type 12 is a rare genetic disorder that causes sparse hair growth due to mutations in the RPL21 gene, inherited in an autosomal dominant manner.
How is Hypotrichosis Type 12 inherited?
It is inherited in an autosomal dominant pattern, meaning a person only needs one copy of the mutated gene from either parent to develop the condition.
What are the symptoms of Hypotrichosis Type 12?
Symptoms include sparse, thin, brittle hair from childhood, and may involve absent eyebrows, eyelashes, and body hair.
How is Hypotrichosis Type 12 diagnosed?
Diagnosis is based on clinical examination and genetic testing, such as the RPL21 Gene NGS Genetic Test, to identify mutations in the RPL21 gene.
What is NGS genetic testing?
Next-generation sequencing (NGS) is a advanced genetic testing method that analyzes multiple genes simultaneously to detect specific mutations, like those in the RPL21 gene.
What is the cost of the RPL21 Gene Hypotrichosis Type 12 NGS Genetic Test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available in 3 to 4 weeks after sample collection.
Is this test covered by insurance?
Coverage depends on individual insurance plans; it is not typically covered under government schemes like PMJAY or CGHS. Check with your provider.
Can Hypotrichosis Type 12 be prevented?
As a genetic disorder, it cannot be prevented, but genetic testing can help with early diagnosis and family planning to assess risks for future generations.
What treatments are available for Hypotrichosis Type 12?
There is no cure, but management may include cosmetic solutions, hair care strategies, and genetic counseling for family support.
How do I book the RPL21 Gene Hypotrichosis Type 12 NGS Genetic Test?
You can book the test online through DNA Labs India's website or contact their customer service for assistance with sample collection and testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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