Serotonin (5-HT) 24 Hour Urine Test
Short Name: Serotonin 24-Hour Urine Test
Also known as: 5-HT Urine Test, Serotonin Urine Test, 24-Hour Urine Serotonin
Serotonin (5-HT) 24 Hour Urine Test test available at DNA Labs India for ₹6,500. Uses LC-MS/MS on 50 mL (10 mL min.) aliquot of 24-hour urine samples. Results in Reports available within 2 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
This test is used to diagnose serotonin imbalances and aid in the detection of carcinoid tumors, particularly foregut carcinoids that produce 5-HTP. It helps in evaluating conditions like depression, anxiety, migraines, fibromyalgia, and gastrointestinal disorders, and guides treatment planning.
- Test Code
- 1414
- Price
- ₹6,500
- Sample Type
- 50 mL (10 mL min.) aliquot of 24-hour urine
- Result Time
- Reports available within 2 days after sample receipt.
- Fasting Required
- No
- Method
- LC-MS/MS
Sample Collection
Patient should strictly avoid specified foods and drugs for at least 48 hours before and during collection. Ensure urine container is prepared with 50% HCl as instructed.
Method: 24-hour urine collection
Laboratory Analysis
Collect all urine over 24 hours in the provided container, keeping it refrigerated. Record total volume on the container and test form.
Report Delivery
Bring the refrigerated or frozen urine sample to the lab for analysis. Follow up with your doctor for result interpretation.
Timeline: Reports available within 2 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
This test is used to diagnose serotonin imbalances and aid in the detection of carcinoid tumors, particularly foregut carcinoids that produce 5-HTP. It helps in evaluating conditions like depression, anxiety, migraines, fibromyalgia, and gastrointestinal disorders, and guides treatment planning.
How to Prepare
- Collect urine for 24 hours in a container with 50% HCl to maintain pH between 1-2
- Do not use concentrated HCl
- Record 24-hour volume on the test request form and urine container
- Ship sample refrigerated or frozen
- Avoid specified foods and drugs 48 hours prior and during collection
- Refrain from strenuous exercise during collection period
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This test is crucial for diagnosing carcinoid tumors and serotonin-related disorders. Ensure proper sample collection and dietary restrictions for accurate results."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Improper urine collection (e.g., not 24 hours)
- Failure to maintain pH with HCl
- Contamination or incorrect storage
- Non-compliance with dietary/medication restrictions
Understanding Your Results
If you experience persistent symptoms like depression, anxiety, migraines, fatigue, or gastrointestinal issues, or if you have a family history of carcinoid tumors, consult your doctor to discuss testing.
Limitations
- ⚠Not specific to all carcinoid tumors; primarily for foregut carcinoids producing 5-HTP
- ⚠Results may be affected by dietary and medication non-compliance
- ⚠Does not measure serotonin in blood or other tissues
Risks & Considerations
- ●No significant risks as it is non-invasive urine collection
- ●Potential for inaccurate results if instructions are not followed
Interfering Factors
- ●Consumption of bananas, walnuts, tomatoes, pineapples, plums, gooseberries, mirabelles, melons, avocados, aubergines, kiwi fruits
- ●Use of drugs like methocarbamol, mephenesin, guaiphenesis, paracetamol, salicylic acid
- ●Strenuous exercise during specimen collection period
- ●Improper urine collection or pH maintenance
Compare With Similar Tests
| Test | Serotonin (5-HT) 24 Hour Urine Test | Chromogranin A Test | 5-Hydroxyindoleacetic Acid (5-HIAA) Test |
|---|---|---|---|
| Comparison | Serotonin (5-HT) 24 Hour Urine Test |
Frequently Asked Questions
What is the Serotonin (5-HT) 24-Hour Urine Test?
Why is this test recommended?
What are common symptoms of serotonin imbalance?
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Is home collection available?
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