SERPINB6 Gene Deafness, autosomal recessive type 91 NGS Genetic Test
Short Name: SERPINB6 Gene Deafness Test
Also known as: SERPINB6-related deafness, DFNB91, Autosomal recessive deafness 91
SERPINB6 Gene Deafness, autosomal recessive type 91 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the SERPINB6 Gene Deafness NGS Genetic Test is to identify mutations in the SERPINB6 gene that cause autosomal recessive deafness type 91. This test aids in confirming diagnosis, guiding treatment strategies, facilitating genetic counseling, and enabling family risk assessment.
- Test Code
- 4755
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
Provide clinical history and family pedigree information. No specific fasting required unless indicated by physician.
Method: Venipuncture
Laboratory Analysis
Blood sample collected via venipuncture by trained phlebotomist. For FTA card, one drop of blood is sufficient.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Resume normal activities.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the SERPINB6 Gene Deafness NGS Genetic Test is to identify mutations in the SERPINB6 gene that cause autosomal recessive deafness type 91. This test aids in confirming diagnosis, guiding treatment strategies, facilitating genetic counseling, and enabling family risk assessment.
How to Prepare
- Ensure proper identification and labeling of samples
- Use sterile collection tubes and follow aseptic techniques
- Transport samples at ambient temperature as per guidelines
- Include completed requisition form with clinical details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for SERPINB6 mutations is crucial for accurate diagnosis, management, and family planning in autosomal recessive deafness cases."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improper labeling or missing documentation
- Contaminated or degraded samples
Understanding Your Results
No pathogenic variants detected
No mutations in SERPINB6 gene identified; deafness may be due to other genetic or environmental factors.
Pathogenic variant detected
Mutation in SERPINB6 gene confirmed; consistent with autosomal recessive deafness type 91. Genetic counseling recommended.
Variant of uncertain significance (VUS)
Genetic variant identified but clinical significance unclear; further testing or family studies may be needed.
Consult a geneticist or ENT specialist if results indicate pathogenic variants, for management planning, or if symptoms persist despite negative results.
Limitations
- ⚠May not detect all genetic variants due to technical limitations
- ⚠Results require interpretation by a geneticist or healthcare provider
- ⚠Does not rule out other genetic or non-genetic causes of deafness
- ⚠Genetic counseling is recommended for result understanding and implications
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or discomfort
- ●Psychological impact of genetic results; counseling available
- ●No significant medical risks from the test itself
Interfering Factors
- ●Sample contamination or degradation
- ●Insufficient DNA quantity or quality
- ●Technical errors in sequencing or analysis
- ●Presence of variants of uncertain significance (VUS) requiring further evaluation
Compare With Similar Tests
| Test | SERPINB6 Gene Deafness, autosomal recessive type 91 NGS Genetic Test | GJB2 Gene Deafness Test | SLC26A4 Gene Test | OTOF Gene Test | Comprehensive Deafness Panel |
|---|---|---|---|---|---|
| Comparison | SERPINB6 Gene Deafness, autosomal recessive type 91 NGS Genetic Test |
Frequently Asked Questions
What is SERPINB6 gene deafness?
How is the NGS genetic test performed?
What is the cost of the SERPINB6 gene deafness test?
Is home sample collection available for this test?
How long does it take to get the test results?
What are the symptoms of SERPINB6 gene deafness?
Who should consider getting this genetic test?
Is the test covered by insurance schemes like PMJAY or CGHS?
What is the accuracy of NGS testing for SERPINB6 mutations?
Can this test detect other genes associated with deafness?
What do the test results mean?
How should I prepare for the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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