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SHBG Gene Androgen-binding protein deficiency NGS Genetic Test

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SHBG Gene Androgen-binding protein deficiency NGS Genetic Test

Short Name: SHBG Gene Test

Also known as: SHBG deficiency, Androgen-binding protein deficiency

SHBG Gene Androgen-binding protein deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify genetic mutations in the SHBG gene causing androgen-binding protein deficiency, aiding in diagnosis, treatment planning, and genetic counseling.

Test Code
5368
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation needed. Provide clinical history and family pedigree during genetic counseling.

Method: Blood Draw

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the site to prevent bleeding. Resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history and draw a pedigree chart.
2
During the Test:Blood sample collection for DNA extraction and NGS analysis.
3
After the Test:Report generation and delivery within 3 to 4 weeks, followed by genetic counseling if needed.

About This Test

Who Should Get This Test

To identify genetic mutations in the SHBG gene causing androgen-binding protein deficiency, aiding in diagnosis, treatment planning, and genetic counseling.

How to Prepare

  • Inform about any medications or supplements
  • Avoid strenuous activity before collection
  • Ensure proper identification and labeling

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for diagnosing rare genetic disorders affecting hormone levels, enabling personalized treatment plans and genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood Draw

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods when stored properly
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect labeling or documentation

Understanding Your Results

Results indicate the presence or absence of mutations in the SHBG gene. Consult a geneticist or endocrinologist for detailed interpretation and next steps.
Positive for pathogenic variant: Indicates SHBG deficiency, may require hormone therapy or treatment
Negative: No mutations detected, symptoms may be due to other causes, further evaluation needed
Variant of uncertain significance: Further testing or family studies may be recommended
⚠️ When to Consult a Doctor:

If you experience symptoms of hormonal imbalance such as low testosterone, infertility, or hirsutism, or have a family history of genetic disorders, consult an endocrinologist or geneticist promptly.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require genetic counseling interpretation
  • ⚠Not a standalone diagnostic tool

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Emotional impact of genetic results, counseling available

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample handling

Frequently Asked Questions

What is SHBG Gene Androgen-binding protein deficiency?
It is a rare genetic disorder caused by mutations in the SHBG gene, leading to reduced production or function of sex hormone-binding globulin, which regulates androgen bioavailability.
How is the NGS Genetic Test performed?
The test involves taking a blood sample, extracting DNA, and using next-generation sequencing to analyze the entire SHBG gene for mutations.
What is the cost of the SHBG Gene Test at DNA Labs India?
The cost is INR 20000, which includes sample collection, genetic analysis, and report generation.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection across numerous cities in India for online bookings.
How long does it take to get the test results?
Results are typically delivered within 3 to 4 weeks via online portal, email, or WhatsApp.
What are the common symptoms of SHBG deficiency?
Symptoms include low testosterone levels, infertility, hirsutism (excessive hair growth), acne, and irregular menstrual periods.
Who should consider getting this genetic test?
Individuals with symptoms of hormonal imbalance, family history of SHBG deficiency, or suspected genetic disorders should consider testing.
Is the test covered by insurance schemes like PMJAY or CGHS?
Coverage varies; it is recommended to check with your insurance provider or scheme administrator for specific details.
What if the test results are positive for a mutation?
A positive result indicates SHBG deficiency, and you should consult an endocrinologist or geneticist for treatment options, which may include hormone therapy.
Can this test be performed on children?
Yes, the test can be performed on individuals of all ages, but genetic counseling is recommended for minors.
How accurate is NGS genetic testing for SHBG deficiency?
NGS testing is highly accurate and comprehensive, but results should be interpreted by a qualified geneticist in the context of clinical history.
What is the difference between this test and a regular SHBG blood test?
This NGS genetic test identifies mutations in the SHBG gene, while a regular SHBG blood test measures hormone levels in the blood; both may be used for diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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