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DNA Labs India

SIX1 Gene Deafness, autosomal dominant type 23 NGS Genetic Test

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SIX1 Gene Deafness, autosomal dominant type 23 NGS Genetic Test

Short Name: SIX1 Gene Deafness Test

Also known as: DFNA23, Autosomal Dominant Deafness Type 23

SIX1 Gene Deafness, autosomal dominant type 23 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the SIX1 gene that cause autosomal dominant type 23 deafness. It helps in confirming diagnosis, understanding inheritance patterns, guiding treatment decisions, and facilitating genetic counselling for families.

Test Code
2300
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Ensure accurate patient identification and clinical history documentation.

Method: Venipuncture for blood samples

Step 2

Laboratory Analysis

Blood sample collected via venipuncture by a trained phlebotomist. FTA card option available for minimal blood volume.

Step 3

Report Delivery

Sample labeled correctly and transported to the lab at ambient temperature. Apply pressure to puncture site to prevent bruising.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling session to discuss test implications and draw a pedigree chart of family members affected with deafness.
2
During the Test:Blood sample collection and DNA extraction for NGS analysis in the laboratory.
3
After the Test:Report generation and delivery within 3 to 4 weeks. Follow-up consultation recommended for result interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the SIX1 gene that cause autosomal dominant type 23 deafness. It helps in confirming diagnosis, understanding inheritance patterns, guiding treatment decisions, and facilitating genetic counselling for families.

How to Prepare

  • Use sterile equipment for blood collection
  • Ensure proper labeling of samples
  • Follow aseptic techniques to avoid contamination
  • For FTA card, apply one drop of blood as per instructions

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for deafness aids in accurate diagnosis and management. Individuals with symptoms or family history should consider this test and consult a genetic counselor."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture for blood samples

Sample Stability

Blood samples stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
FTA card samples stable at room temperature for several days
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples
  • Samples with incorrect patient details

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the SIX1 gene. A positive result confirms a genetic basis for autosomal dominant type 23 deafness, while a negative result suggests no detectable mutations in the gene analyzed.
Positive Result: Pathogenic mutation detected, supporting diagnosis of autosomal dominant type 23 deafness. Genetic counselling advised.
Negative Result: No pathogenic variants found in SIX1 gene. Consider other genetic or non-genetic causes of deafness.
Variant of Uncertain Significance (VUS): Further evaluation and family studies may be needed.
Report includes detailed findings and recommendations for clinical management.
⚠️ When to Consult a Doctor:

Consult a geneticist or ENT specialist if you experience symptoms of hearing loss, have a family history of deafness, or receive a positive test result for further evaluation and management.

Limitations

  • ⚠May not detect all possible genetic variations or mutations
  • ⚠Results should be interpreted in conjunction with clinical history
  • ⚠Genetic counselling is recommended for comprehensive understanding

Risks & Considerations

  • ●Minor bruising or discomfort at blood draw site
  • ●Low risk of infection at puncture site
  • ●Psychological impact of genetic results; counselling available

Interfering Factors

  • ●Degraded or insufficient DNA sample
  • ●Contamination during sample collection
  • ●Recent blood transfusion may affect DNA integrity

Frequently Asked Questions

What is the SIX1 Gene Deafness NGS Genetic Test?
It is a next-generation sequencing test that analyzes the SIX1 gene for mutations causing autosomal dominant type 23 deafness, a hereditary hearing loss condition.
Who should consider this genetic test?
Individuals with symptoms of hearing loss, especially with a family history of autosomal dominant deafness, or those referred by an ENT doctor for genetic evaluation.
What are the symptoms of autosomal dominant type 23 deafness?
Symptoms include difficulty hearing high-pitched sounds, trouble understanding speech in noise, gradual hearing loss, and tinnitus.
How is the test performed?
A blood sample is collected, DNA is extracted, and next-generation sequencing is used to detect mutations in the SIX1 gene.
What is the cost of the test in India?
The cost is INR 20,000 at DNA Labs India, including sample collection, analysis, and report.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for online bookings.
How long does it take to get results?
Reports are typically delivered within 3 to 4 weeks via online portal, email, or WhatsApp.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the SIX1 gene, confirming the genetic cause of deafness. Genetic counselling is recommended.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw. The test itself is safe and non-invasive.
How should I prepare for the test?
No fasting is required. Provide accurate clinical history and ensure proper sample collection by a trained professional.
Can this test be used for prenatal diagnosis?
The test is designed for postnatal diagnosis. Prenatal genetic testing may be available through specialized labs, but consult a geneticist for options.
Where can I get this test done?
DNA Labs India provides this test with services in numerous cities across India. Visit their website or contact them for booking.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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