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SLC26A5 Gene Deafness, autosomal recessive type 61 NGS Genetic Test

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SLC26A5 Gene Deafness, autosomal recessive type 61 NGS Genetic Test

Short Name: SLC26A5 Deafness NGS Test

Also known as: DFNB61, SLC26A5-related Deafness, Autosomal Recessive Deafness 61

SLC26A5 Gene Deafness, autosomal recessive type 61 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect pathogenic mutations in the SLC26A5 gene using next-generation sequencing for the diagnosis of autosomal recessive deafness type 61 (DFNB61).

Test Code
4740
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Provide detailed clinical history and family pedigree during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is collected via venipuncture from a vein in the arm.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. The sample is labeled and transported to the laboratory for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss the test, provide informed consent, and document family history.
2
During the Test:Sample collection procedure takes a few minutes; no special actions required from the patient.
3
After the Test:Wait for the report, which will be delivered in 3-4 weeks. Follow up with a genetic counselor for result interpretation.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the SLC26A5 gene using next-generation sequencing for the diagnosis of autosomal recessive deafness type 61 (DFNB61).

How to Prepare

  • Ensure proper patient identification and sample labeling
  • Use sterile collection tubes
  • Transport the sample at ambient room temperature
  • Avoid hemolysis during blood draw

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is essential for diagnosing hereditary deafness linked to SLC26A5 mutations, aiding in family planning and management."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples: Stable for 24-48 hours at room temperature
Extracted DNA: Stable for longer periods when stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Incorrect sample container or labeling
  • Samples older than stability period

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the SLC26A5 gene, helping diagnose autosomal recessive deafness type 61.
Positive Result: Pathogenic mutation detected, confirming diagnosis of SLC26A5-related deafness
Negative Result: No pathogenic variants found, but clinical correlation is necessary as other genetic or non-genetic causes may exist
Variant of Uncertain Significance (VUS): Genetic variant identified with unclear clinical impact; further testing or family studies recommended
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of hearing loss, have a family history of deafness, or receive a positive genetic test result for further management and counseling.

Limitations

  • ⚠May not detect all types of mutations, such as large deletions or duplications
  • ⚠Results require interpretation by a genetic counselor or specialist
  • ⚠Not diagnostic for all forms of hearing loss
  • ⚠Variant of uncertain significance (VUS) may be identified, needing further evaluation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results, including anxiety or stress
  • ●Potential for incidental findings unrelated to deafness

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Technical errors during sequencing
  • ●Insufficient sample volume

Frequently Asked Questions

What is the SLC26A5 gene?
The SLC26A5 gene encodes prestin, a protein essential for outer hair cell function in the inner ear, crucial for hearing.
What is autosomal recessive deafness type 61?
It is a form of inherited hearing loss caused by mutations in the SLC26A5 gene, following an autosomal recessive pattern.
How is the SLC26A5 gene test performed?
The test uses next-generation sequencing (NGS) to analyze the SLC26A5 gene for mutations from a blood or DNA sample.
What is the cost of the SLC26A5 genetic test?
The test costs INR 20000.0, with home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What do positive results indicate?
Positive results confirm the presence of pathogenic mutations in the SLC26A5 gene, diagnosing autosomal recessive deafness type 61.
Is genetic counseling required before or after the test?
Yes, genetic counseling is recommended to discuss test implications, results, and family planning.
Can this test detect all mutations causing deafness?
No, it specifically targets SLC26A5 gene mutations; other genetic or non-genetic causes may require different tests.
What are the risks associated with this genetic test?
Risks are minimal, primarily related to blood draw, but may include psychological impact from results.
Is the test covered by insurance or government schemes?
Coverage varies; it is not typically covered by schemes like PMJAY or CGHS, but check with your insurer.
How accurate is the NGS test for SLC26A5 mutations?
NGS is highly accurate for detecting small mutations, but accuracy depends on sample quality and laboratory standards.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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