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SLC4A5 Gene Renal tubular acidosis, SLC4A5 related NGS Genetic Test

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SLC4A5 Gene Renal tubular acidosis, SLC4A5 related NGS Genetic Test

Short Name: SLC4A5 RTA NGS Test

Also known as: SLC4A5 RTA Test, Renal Tubular Acidosis Genetic Test, NBCe1 Gene Test

SLC4A5 Gene Renal tubular acidosis, SLC4A5 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the SLC4A5 gene associated with renal tubular acidosis, aiding in diagnosis, risk assessment, and family planning.

Test Code
5509
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide detailed clinical history and attend a genetic counselling session to draw a pedigree chart of affected family members.

Method: Venipuncture or FTA Card spot collection

Step 2

Laboratory Analysis

Standard blood draw from a vein or spot collection on FTA card.

Step 3

Report Delivery

Sample is processed for DNA extraction and NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling and clinical history review are recommended before sample collection.
2
During the Test:Blood sample collection via venipuncture or FTA card.
3
After the Test:Sample sent to lab for NGS analysis; results available in 3-4 weeks.

About This Test

Who Should Get This Test

To identify mutations in the SLC4A5 gene associated with renal tubular acidosis, aiding in diagnosis, risk assessment, and family planning.

How to Prepare

  • Ensure patient provides complete clinical history
  • Schedule genetic counselling prior to test
  • Use sterile collection techniques
  • Label samples accurately

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS test is essential for identifying genetic causes of renal tubular acidosis, enabling targeted treatment and family screening."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or FTA Card spot collection

Sample Stability

Blood: 2-8°C for 72 hours
FTA Card: Room temperature for extended periods
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the SLC4A5 gene. Positive results suggest a genetic predisposition to renal tubular acidosis.
Positive: Pathogenic variant detected – correlate with clinical symptoms and family history.
Negative: No pathogenic variants – consider other genetic or non-genetic causes.
Variant of uncertain significance (VUS) – requires further evaluation and genetic counselling.
⚠️ When to Consult a Doctor:

If you experience symptoms of RTA, have a family history of the condition, or receive a positive test result, consult a nephrologist or geneticist for management.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other causes of RTA

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection, or discomfort

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Recent blood transfusions

Frequently Asked Questions

What is SLC4A5 gene renal tubular acidosis?
It is a genetic condition caused by mutations in the SLC4A5 gene, leading to impaired kidney function in excreting acids, resulting in renal tubular acidosis.
What are the common symptoms of this condition?
Symptoms include fatigue, muscle weakness, bone pain, increased urine output, dehydration, and electrolyte imbalances.
How is SLC4A5 gene RTA diagnosed?
Diagnosis involves blood and urine tests to assess acid-base balance, along with genetic testing to identify mutations in the SLC4A5 gene.
What is the cost of the NGS Genetic Test for SLC4A5?
The test costs INR 20,000, which includes home sample collection across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What sample is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Who should consider getting this test?
Individuals with symptoms of RTA, family history of the condition, or unexplained metabolic acidosis should consider this test.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising or discomfort. Genetic testing itself has no physical risks.
How accurate is the NGS Genetic Test for SLC4A5?
NGS technology is highly accurate for detecting genetic mutations, but results should be interpreted in clinical context.
What should I do if I test positive for SLC4A5 mutations?
Consult a nephrologist or geneticist for further evaluation, management, and family screening.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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