SMPX Gene Deafness, X-linked type 4 NGS Genetic Test
Short Name: SMPX Gene Deafness Test
Also known as: X-linked deafness type 4, SMPX-related hearing loss, DFNX4
SMPX Gene Deafness, X-linked type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the SMPX Gene Deafness NGS Genetic Test is to identify mutations in the SMPX gene that cause X-linked type 4 hearing loss. This test aids in accurate diagnosis, genetic counseling, family planning, and personalized management of hearing impairment.
- Test Code
- 4763
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No specific preparation is required. Provide clinical history and family pedigree for accurate interpretation.
Method: Venipuncture or finger-prick for FTA card
Laboratory Analysis
A blood sample will be collected via venipuncture or a finger-prick for FTA card. The process is quick and minimally invasive.
Report Delivery
Apply pressure to the collection site to prevent bruising. Resume normal activities immediately.
Timeline: 3 to 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the SMPX Gene Deafness NGS Genetic Test is to identify mutations in the SMPX gene that cause X-linked type 4 hearing loss. This test aids in accurate diagnosis, genetic counseling, family planning, and personalized management of hearing impairment.
How to Prepare
- Ensure proper identification of the patient.
- Use sterile collection equipment.
- Label samples correctly with patient details.
- Transport samples at ambient temperature as per guidelines.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for SMPX gene deafness is crucial for accurate diagnosis and management of hearing loss, especially in families with a history of X-linked conditions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrect labeling or missing patient information
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of SMPX gene-related deafness. Genetic counseling and management options should be discussed.
No pathogenic variant detected
SMPX gene mutations are not identified. Consider other genetic or non-genetic causes of hearing loss.
Variant of uncertain significance (VUS)
Further testing or family studies may be required for clarification.
Consult a doctor or genetic counselor if you have a family history of hearing loss, experience symptoms of deafness, or receive a positive test result for guidance on management and family planning.
Limitations
- ⚠This test only detects mutations in the SMPX gene; other genetic causes of deafness are not covered.
- ⚠Results may require confirmation with additional testing or clinical correlation.
- ⚠Not all mutations may be detected due to technical limitations of NGS.
Risks & Considerations
- ●Minimal risks from blood collection, such as bruising or infection.
- ●Psychological impact of genetic results; genetic counseling is recommended.
Interfering Factors
- ●Contaminated or degraded DNA samples
- ●Recent blood transfusions may affect DNA analysis
- ●Technical errors in sample collection or processing
Compare With Similar Tests
| Test | SMPX Gene Deafness, X-linked type 4 NGS Genetic Test | GJB2 Gene Test | Comprehensive Hearing Loss Panel |
|---|---|---|---|
| Comparison | SMPX Gene Deafness, X-linked type 4 NGS Genetic Test | Detects mutations in the GJB2 gene, a common cause of autosomal recessive hearing loss, unlike SMPX which is X-linked. | Includes multiple genes associated with hearing loss, providing broader coverage than single-gene SMPX testing. |
Frequently Asked Questions
What is SMPX gene deafness?
How is the SMPX Gene Deafness Test performed?
What is the cost of the SMPX Gene Deafness Test?
Is home sample collection available for this test?
How long does it take to get results?
What are the symptoms of SMPX gene deafness?
Who should consider getting this test?
Is the test covered by insurance?
What is the accuracy of NGS testing for SMPX gene?
Can females be affected by SMPX gene deafness?
What should I do if I test positive for SMPX gene mutation?
How can I book the SMPX Gene Deafness Test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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