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TAC3 Gene Hypogonadotropic hypogonadism type 10 with or without anosmia NGS Genetic Test

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TAC3 Gene Hypogonadotropic hypogonadism type 10 with or without anosmia NGS Genetic Test

Short Name: TAC3 HH Type 10 NGS Test

Also known as: HH Type 10, TAC3 Gene Mutation Test, Congenital Hypogonadotropic Hypogonadism Type 10

TAC3 Gene Hypogonadotropic hypogonadism type 10 with or without anosmia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose mutations in the TAC3 gene causing hypogonadotropic hypogonadism type 10, enabling early intervention and management of reproductive and olfactory symptoms.

Test Code
5437
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Provide clinical history and undergo genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is drawn from a vein in the arm using standard venipuncture techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Keep the area clean.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counseling to discuss test implications and family history.
2
During the Test:Blood sample collection and DNA extraction for NGS analysis.
3
After the Test:Review results with a healthcare provider and plan management.

About This Test

Who Should Get This Test

To diagnose mutations in the TAC3 gene causing hypogonadotropic hypogonadism type 10, enabling early intervention and management of reproductive and olfactory symptoms.

How to Prepare

  • Ensure proper labeling of samples
  • Transport at ambient room temperature
  • Use sterile collection tubes

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for diagnosing genetic causes of hypogonadism, guiding personalized treatment, and informing family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood: stable for 48 hours at room temperature
Extracted DNA: stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the TAC3 gene. Positive results confirm a genetic cause for symptoms, while negative results may require further testing.
📊

Positive

Pathogenic mutation detected in TAC3 gene, confirming diagnosis.

📊

Negative

No pathogenic variants detected; consider other genetic or non-genetic causes.

📊

Variant of uncertain significance

Genetic change found but clinical significance unknown; further evaluation needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of hypogonadism, have a family history of the condition, or for guidance on test results and treatment options.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results may have implications for family members

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated sample
  • ●Degraded DNA
  • ●Improper sample storage

Compare With Similar Tests

TestTAC3 Gene Hypogonadotropic hypogonadism type 10 with or without anosmia NGS Genetic Test
ComparisonTAC3 Gene Hypogonadotropic hypogonadism type 10 with or without anosmia NGS Genetic Test

Frequently Asked Questions

What is the TAC3 Gene Hypogonadotropic Hypogonadism Type 10 NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the TAC3 gene, which causes a rare form of hypogonadism with or without anosmia.
Who should consider this test?
Individuals with symptoms like delayed puberty, infertility, anosmia, or a family history of hypogonadotropic hypogonadism.
How is the test performed?
A blood sample is collected, DNA is extracted, and the TAC3 gene is sequenced using NGS technology.
What is the cost of the test?
The test costs INR 20,000 in India, with possible discounts for online bookings.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across many cities in India.
How long does it take to get results?
Reports are typically delivered within 3-4 weeks after sample collection.
What do the results mean?
Positive results indicate a mutation in the TAC3 gene, confirming the diagnosis. Negative results suggest no known mutations, but further evaluation may be needed.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising. Genetic results may have emotional implications.
Can this test diagnose other forms of hypogonadism?
No, it specifically targets TAC3 gene mutations. Other genetic tests are available for different forms.
Is genetic counseling required?
Yes, genetic counseling is recommended before and after testing to understand results and family risks.
How accurate is the NGS technology?
NGS is highly accurate for detecting genetic mutations, but no test is 100% foolproof; clinical correlation is advised.
What should I do if the test is positive?
Consult an endocrinologist or geneticist for treatment options, which may include hormone therapy and ongoing monitoring.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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