TBII Thyrotropin - Binding Inhibitory Immunoglobulin Test
Short Name: TBII Test
Also known as: Thyrotropin-Binding Inhibitory Immunoglobulin Test, TBII Test
TBII Thyrotropin - Binding Inhibitory Immunoglobulin Test test available at DNA Labs India for ₹13,771. Uses Radioreceptor Assay on Serum samples. Results in Reports are issued 2-3 weeks after sample submission (sample accepted by the 7th of the month).. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The TBII test is used to diagnose and manage Graves' disease, neonatal hypothyroidism, and postpartum thyroid dysfunction.
- Test Code
- 3681
- Price
- ₹13,771
- Sample Type
- Serum
- Result Time
- Reports are issued 2-3 weeks after sample submission (sample accepted by the 7th of the month).
- Fasting Required
- No
- Method
- Radioreceptor Assay
Sample Collection
No fasting is required. Please carry a valid prescription and the duly filled Test Send Out Consent Form (Form 35).
Method: Blood sample
Laboratory Analysis
A trained phlebotomist will collect a blood sample from the antecubital vein.
Report Delivery
No special precautions are required. You can resume normal activities.
Timeline: Reports are issued 2-3 weeks after sample submission (sample accepted by the 7th of the month).
Patient Instructions
About This Test
Who Should Get This Test
The TBII test is used to diagnose and manage Graves' disease, neonatal hypothyroidism, and postpartum thyroid dysfunction.
How to Prepare
- Duly filled Test Send Out Consent Form (Form 35) is mandatory.
- Collect serum from 1 SST (2 mL whole blood; min 1 mL serum).
- Ship samples refrigerated or frozen.
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The TBII test is valuable in identifying autoimmune thyroid disease. However, it should never be interpreted in isolation; clinical context is key."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic specimens
- Incorrect labeling
- Incomplete or missing consent form
- Inadequate sample volume
Understanding Your Results
Positive (≥1.75 U/L)
Supports the diagnosis of Graves' disease; may be seen in active disease.
Negative (<1.75 U/L)
Does not rule out Graves' disease; clinical correlation is essential.
High titre in pregnancy
Requires monitoring for neonatal thyroid dysfunction.
If you have persistent symptoms of hyperthyroidism such as irregular heartbeat, significant weight loss, or eye changes, consult an endocrinologist immediately.
Limitations
- ⚠TBII does not differentiate between stimulating (TSI) and blocking antibodies.
- ⚠A negative TBII result does not exclude Graves' disease.
- ⚠Results should be interpreted alongside thyroid function tests.
Risks & Considerations
- ●Pain or bruising at the needle site
- ●Light-headedness
- ●Very small risk of infection
Interfering Factors
- ●Pregnancy may cause physiological changes in thyroid antibody levels.
- ●Use of immunosuppressive drugs may affect results.
- ●High levels of other immunoglobulins may interfere.
- ●Radiological contrast agents or radioactive iodine exposure.
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Frequently Asked Questions
What is the TBII test?
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Is TBII the same as TSI?
Can the TBII test be done during pregnancy?
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