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TCF12 Gene Craniosynostosis type 3 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

TCF12 Gene Craniosynostosis type 3 NGS Genetic Test

Short Name: TCF12 Craniosynostosis NGS Test

Also known as: TCF12-related craniosynostosis, Craniosynostosis type 3 genetic test

TCF12 Gene Craniosynostosis type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

PediatricsInfants and Children🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the TCF12 Gene Craniosynostosis Type 3 NGS Genetic Test is to identify mutations in the TCF12 gene that cause craniosynostosis type 3, enabling accurate diagnosis, personalized treatment, genetic counseling, and early detection for at-risk family members.

Test Code
2708
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling is recommended. Provide clinical history and family pedigree.

Method: Venipuncture or blood drop

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or blood drop on FTA card by trained phlebotomist.

Step 3

Report Delivery

Sample sent to lab for analysis. Await report for 3-4 weeks.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss implications, risks, and benefits. Provide informed consent.
2
During the Test:Sample collection procedure as per instructions. Minimal discomfort from blood draw.
3
After the Test:Wait for report. Schedule follow-up with healthcare provider for result interpretation.

About This Test

Who Should Get This Test

The purpose of the TCF12 Gene Craniosynostosis Type 3 NGS Genetic Test is to identify mutations in the TCF12 gene that cause craniosynostosis type 3, enabling accurate diagnosis, personalized treatment, genetic counseling, and early detection for at-risk family members.

How to Prepare

  • Ensure proper identification
  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for craniosynostosis type 3 is essential for early intervention, family planning, and personalized management of affected individuals."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or blood drop

Sample Stability

Blood: 2-8°C for 7 days
FTA card: Room temperature for 30 days
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or clotted sample
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the TCF12 gene. Positive results confirm craniosynostosis type 3, while negative results may require further testing.
📊

Positive for pathogenic variant

Confirms diagnosis of craniosynostosis type 3. Genetic counseling and management planning recommended.

📊

Negative for pathogenic variant

No mutations detected in TCF12 gene. Consider other genetic or non-genetic causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

Consult a geneticist or pediatrician if symptoms persist, for genetic counseling, or to discuss test results and management options.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Improper sample storage

Compare With Similar Tests

TestTCF12 Gene Craniosynostosis type 3 NGS Genetic TestFGFR2 Gene Craniosynostosis TestWhole Exome Sequencing
ComparisonTCF12 Gene Craniosynostosis type 3 NGS Genetic TestTargets different gene for craniosynostosis; may be complementary.Broader genetic analysis; higher cost but may detect additional variants.

Frequently Asked Questions

What is TCF12 Gene Craniosynostosis Type 3?
It is a rare genetic condition caused by mutations in the TCF12 gene, leading to premature fusion of skull bones in infants and children.
Who should consider this genetic test?
Individuals with symptoms like abnormal skull shape, developmental delays, or a family history of craniosynostosis should consider testing.
How is the test performed?
The test uses next-generation sequencing (NGS) to analyze DNA from a blood sample or extracted DNA for mutations in the TCF12 gene.
What is the cost of the TCF12 Gene NGS Genetic Test?
The cost is INR 20,000 in India, which may include home sample collection and report delivery.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results mean?
Positive results confirm a diagnosis of craniosynostosis type 3, while negative results may indicate no mutation in the TCF12 gene. Genetic counseling is recommended for interpretation.
Is genetic counseling required before testing?
Yes, genetic counseling is recommended to understand the implications, risks, and benefits of testing, and to draw a family pedigree chart.
Can this test detect all mutations causing craniosynostosis?
The test specifically targets the TCF12 gene; other genes may be involved, so additional testing might be needed.
Is the test covered by insurance?
Coverage varies by insurance provider; it is not typically covered under government schemes like PMJAY or CGHS. Check with your insurer.
What are the risks of the test?
Risks are minimal, primarily related to blood draw, such as bruising. Psychological impact of results is also a consideration.
How do I prepare for the test?
No fasting is required. Provide clinical history and undergo genetic counseling. Ensure proper identification during sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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