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THRB Gene Thyroid hormone resistance NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

THRB Gene Thyroid hormone resistance NGS Genetic Test

Short Name: THRB Gene Test

Also known as: Thyroid Hormone Resistance Genetic Test, THRB Mutation Analysis, Resistance to Thyroid Hormone Test

THRB Gene Thyroid hormone resistance NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose thyroid hormone resistance by detecting mutations in the THRB gene through NGS technology, aiding in clinical management and family planning.

Test Code
2653
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo a genetic counseling session to draw a pedigree chart of affected family members.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or using an FTA card for one drop blood.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review to assess appropriateness of testing.
2
During the Test:Blood sample collection and DNA extraction for NGS sequencing of the THRB gene.
3
After the Test:Report generation and consultation with healthcare provider to discuss results and next steps.

About This Test

Who Should Get This Test

To diagnose thyroid hormone resistance by detecting mutations in the THRB gene through NGS technology, aiding in clinical management and family planning.

How to Prepare

  • No fasting typically required for genetic tests.
  • Bring identification and prescription.
  • Inform about any medications or supplements.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"If you have symptoms of thyroid hormone resistance, such as unexplained weight gain or fatigue, genetic testing can provide clarity. Consult a genetic counselor for personalized advice."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the THRB gene associated with thyroid hormone resistance.
📊

No pathogenic variants detected

Normal THRB gene function; thyroid hormone resistance unlikely due to THRB mutations. Clinical correlation advised.

📊

Pathogenic variant detected

Mutation in THRB gene identified; consistent with thyroid hormone resistance. Genetic counseling and specialist consultation recommended.

⚠️ When to Consult a Doctor:

If you experience symptoms like persistent fatigue, weight gain, or infertility, or if genetic test results indicate a mutation, consult an endocrinologist or geneticist for further evaluation.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires clinical correlation
  • ⚠Genetic counseling recommended for interpretation

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection, or dizziness.

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

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Frequently Asked Questions

What is the THRB Gene Thyroid Hormone Resistance NGS Genetic Test?
It is a genetic test that sequences the THRB gene to identify mutations causing thyroid hormone resistance, a condition where the body doesn't respond properly to thyroid hormones.
How much does the test cost?
The test costs INR 20,000, with free home sample collection available across India.
What are the symptoms of thyroid hormone resistance?
Symptoms include weight gain, fatigue, depression, constipation, muscle weakness, joint pain, irregular menstrual periods, infertility, and delayed growth in children.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) technology to analyze DNA from a blood sample for mutations in the THRB gene.
What sample is required for the test?
A blood sample, extracted DNA, or one drop of blood on an FTA card is required.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What does a positive result mean?
A positive result indicates a pathogenic variant in the THRB gene, suggesting thyroid hormone resistance. Genetic counseling is recommended for interpretation.
Can children undergo this test?
Yes, the test is suitable for all ages, including children with symptoms like delayed growth and development.
Is genetic counseling necessary?
Yes, genetic counseling is advised before and after testing to understand implications and guide management.
How accurate is the NGS technology?
NGS technology is highly accurate for detecting genetic mutations, but results should be correlated with clinical findings.
What should I do if I have a family history of thyroid disorders?
Consult a doctor or genetic counselor to determine if genetic testing is appropriate based on family history and symptoms.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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