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TMPRSS3 Gene Deafness, autosomal recessive type 8/10 NGS Genetic Test

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TMPRSS3 Gene Deafness, autosomal recessive type 8/10 NGS Genetic Test

Short Name: TMPRSS3 Deafness NGS Test

Also known as: DFNB8/10 Deafness, TMPRSS3-Related Hearing Loss

TMPRSS3 Gene Deafness, autosomal recessive type 8/10 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect pathogenic mutations in the TMPRSS3 gene that cause autosomal recessive type 8/10 deafness, aiding in diagnosis, management, and genetic counseling.

Test Code
4748
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Inform the healthcare provider about any medications or recent transfusions.

Method: Blood draw or cheek swab

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm, or a cheek swab will be taken. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:No fasting required. Provide clinical history and family pedigree during genetic counseling.
2
During the Test:Sample collection via blood draw or cheek swab. The test is performed in a laboratory using NGS technology.
3
After the Test:Results are available in 3-4 weeks. Genetic counseling is provided to interpret findings.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the TMPRSS3 gene that cause autosomal recessive type 8/10 deafness, aiding in diagnosis, management, and genetic counseling.

How to Prepare

  • Ensure proper identification of the patient.
  • Use sterile equipment for blood collection or cheek swab.
  • Label the sample correctly with patient details.
  • Transport the sample to the lab at ambient temperature as specified.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for TMPRSS3 mutations is crucial for diagnosing hereditary deafness, guiding management, and informing family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood or equivalent
ContainerEDTA tube or FTA card
Collection MethodBlood draw or cheek swab

Sample Stability

Blood samples: Stable for 48 hours at room temperature.
FTA card samples: Stable for years if stored properly.
Sample Rejection Criteria:
  • Incorrectly labeled or unlabeled samples
  • Insufficient sample volume
  • Contaminated or hemolyzed samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the TMPRSS3 gene. A positive result confirms a genetic cause for deafness, while a negative result suggests other etiologies may be involved.
Positive: Pathogenic variants detected – indicates autosomal recessive deafness type 8/10. Genetic counseling recommended.
Negative: No pathogenic variants detected – does not rule out other genetic or non-genetic causes of deafness.
Variant of uncertain significance (VUS): Further testing and family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a genetic counselor or ENT specialist if you have a family history of deafness, symptoms of hearing loss, or after receiving test results for personalized management.

Limitations

  • ⚠This test only analyzes the TMPRSS3 gene; other genetic causes of deafness may not be identified.
  • ⚠May not detect all types of mutations, such as large deletions or duplications.
  • ⚠Results require interpretation by a certified genetic counselor for clinical relevance.

Risks & Considerations

  • ●Minimal risk from blood draw: slight pain, bruising, or infection at puncture site.
  • ●No significant risks from cheek swab collection.

Interfering Factors

  • ●Hemolyzed or contaminated blood samples
  • ●Degraded DNA due to improper storage
  • ●Recent blood transfusions may affect results

Compare With Similar Tests

TestTMPRSS3 Gene Deafness, autosomal recessive type 8/10 NGS Genetic TestGJB2 Gene Deafness TestSLC26A4 Gene TestOTOF Gene TestComprehensive Deafness Panel
ComparisonTMPRSS3 Gene Deafness, autosomal recessive type 8/10 NGS Genetic Test

Frequently Asked Questions

What is the TMPRSS3 gene?
The TMPRSS3 gene provides instructions for making a protein involved in the development and function of the inner ear. Mutations in this gene can cause autosomal recessive deafness type 8/10.
What is autosomal recessive type 8/10 deafness?
It is a genetic form of hearing loss caused by mutations in the TMPRSS3 gene, inherited in an autosomal recessive pattern, meaning both parents must carry a mutation for a child to be affected.
How is the NGS Genetic Test performed?
The test uses next-generation sequencing to analyze DNA from a blood sample or cheek swab, detecting mutations in the TMPRSS3 gene.
What does a positive test result mean?
A positive result indicates the presence of pathogenic mutations in the TMPRSS3 gene, confirming a genetic cause for deafness. Genetic counseling is recommended for interpretation and next steps.
Is the test painful?
The test involves a simple blood draw or cheek swab, which may cause minimal discomfort but is generally not painful.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Can this test be done on children?
Yes, the test can be performed on individuals of all ages, including infants and children, with appropriate sample collection methods.
Is genetic counseling required before the test?
Genetic counseling is highly recommended to understand the implications of testing, draw a family pedigree, and interpret results accurately.
What are the risks of the test?
Risks are minimal and related to sample collection, such as slight pain or bruising from a blood draw. There are no significant risks from the test itself.
How accurate is the test?
The NGS Genetic Test is highly accurate for detecting mutations in the TMPRSS3 gene, but no test is 100% foolproof. Results should be interpreted by a genetic counselor.
Can the test detect all mutations causing deafness?
No, this test only analyzes the TMPRSS3 gene. Other genetic causes of deafness may require different tests or a comprehensive panel.
What should I do after receiving the results?
Consult a genetic counselor or ENT specialist to discuss the results, understand management options, and consider family planning if applicable.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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