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DNA Labs India

TP63 Gene ADULT syndrome, split hand-foot malformation NGS Genetic Test

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TP63 Gene ADULT syndrome, split hand-foot malformation NGS Genetic Test

Short Name: TP63 Gene ADULT Syndrome NGS Test

Also known as: Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome, ADULT Syndrome

TP63 Gene ADULT syndrome, split hand-foot malformation NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatrics🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose ADULT syndrome by detecting mutations in the TP63 gene using next-generation sequencing (NGS) technology, enabling accurate identification and management of the condition.

Test Code
5643
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample will be drawn via venipuncture by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling. No fasting required.
2
During the Test:Blood sample collection via venipuncture, which takes a few minutes.
3
After the Test:Resume normal activities. Results will be available in 3 to 4 weeks.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose ADULT syndrome by detecting mutations in the TP63 gene using next-generation sequencing (NGS) technology, enabling accurate identification and management of the condition.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment
  • Label samples correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for diagnosing ADULT syndrome in patients with suggestive symptoms, aiding in management and genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods at appropriate storage
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the TP63 gene. Positive results confirm ADULT syndrome, while negative results may require further testing if clinical suspicion remains.
📊

Pathogenic variant detected

Confirms diagnosis of ADULT syndrome. Genetic counseling recommended.

📊

No pathogenic variant detected

ADULT syndrome unlikely, but consider other genetic tests if symptoms persist.

📊

Variant of uncertain significance

Further analysis and family studies may be needed.

⚠️ When to Consult a Doctor:

If symptoms of ADULT syndrome are present, such as split hand-foot malformation or other associated features, or if there is a family history of the disorder.

Limitations

  • ⚠May not detect all types of mutations, such as large deletions or duplications
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood samples

Frequently Asked Questions

What is ADULT syndrome?
ADULT syndrome is a rare genetic disorder caused by mutations in the TP63 gene, affecting skin, teeth, and limbs, often with split hand-foot malformation.
What causes ADULT syndrome?
It is caused by mutations in the TP63 gene, which is involved in the development of ectodermal structures.
How is ADULT syndrome diagnosed?
Diagnosis is based on clinical symptoms and confirmed through genetic testing, such as NGS for the TP63 gene.
What is the cost of the TP63 gene NGS test?
The test costs INR 20,000 at DNA Labs India, with home sample collection available.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks.
What samples are required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Can the test detect all mutations in the TP63 gene?
NGS is comprehensive but may not detect all mutation types; genetic counseling is recommended.
What are the risks of the test?
Risks are minimal, including minor bruising from blood draw and psychological impact of results.
Is genetic counseling recommended?
Yes, genetic counseling is advised before and after testing to understand implications.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting mutations, but results should be interpreted by a genetic specialist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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