TRMU Gene Liver failure transient infantile NGS Genetic Test
Short Name: TRMU Gene NGS Test
Also known as: TRMU-related liver failure, Transient infantile liver failure due to TRMU mutation
TRMU Gene Liver failure transient infantile NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the TRMU Gene NGS Genetic Test is to detect mutations in the TRMU gene that cause transient infantile liver failure. This test aids in accurate diagnosis, informs treatment strategies, and supports genetic counseling for affected families.
- Test Code
- 2615
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Provide clinical history and undergo genetic counseling to draw a pedigree chart. No specific preparation is required, but ensure the infant is stable for blood collection.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected via venipuncture from the infant or using an FTA card for a drop of blood. The process is quick and minimally invasive.
Report Delivery
Apply pressure to the collection site to prevent bleeding. Keep the infant comfortable and monitor for any signs of discomfort.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the TRMU Gene NGS Genetic Test is to detect mutations in the TRMU gene that cause transient infantile liver failure. This test aids in accurate diagnosis, informs treatment strategies, and supports genetic counseling for affected families.
How to Prepare
- Ensure proper identification of the patient
- Use sterile equipment for blood collection
- Label the sample correctly with patient details
- Transport the sample to the lab at ambient room temperature
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for TRMU mutations is crucial for diagnosing transient infantile liver failure, enabling timely intervention and improved prognosis for affected infants."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrectly labeled or contaminated samples
Understanding Your Results
Positive for pathogenic TRMU mutation
Confirms diagnosis of liver failure transient infantile. Genetic counseling and targeted treatment are recommended.
Negative for pathogenic mutations
TRMU gene mutations not detected. Consider other genetic or metabolic causes of liver failure.
Variant of uncertain significance (VUS)
Further testing and family studies may be needed to determine clinical significance.
Consult a doctor immediately if your infant shows symptoms such as jaundice, poor feeding, vomiting, or respiratory distress. Early consultation is vital for diagnosis and management.
Limitations
- ⚠May not detect all possible mutations in the TRMU gene
- ⚠Results require interpretation by a genetic counselor or specialist
- ⚠Does not rule out other genetic or non-genetic causes of liver failure
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection
- ●Psychological impact of genetic results on families
- ●Potential for uncertain results requiring further investigation
Interfering Factors
- ●Contaminated or degraded DNA samples
- ●Improper sample collection or storage
- ●Recent blood transfusions may affect DNA analysis
Compare With Similar Tests
| Test | TRMU Gene Liver failure transient infantile NGS Genetic Test | Comprehensive Metabolic Panel | Whole Exome Sequencing | Targeted Gene Panel for Liver Diseases |
|---|---|---|---|---|
| Comparison | TRMU Gene Liver failure transient infantile NGS Genetic Test |
Frequently Asked Questions
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