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TRPC6 Gene Focal segmental glomerulosclerosis type 2 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

TRPC6 Gene Focal segmental glomerulosclerosis type 2 NGS Genetic Test

Short Name: TRPC6 Gene FSGS2 NGS Genetic Test

Also known as: FSGS2 Genetic Test, TRPC6 Mutation Analysis, Focal Segmental Glomerulosclerosis Type 2 DNA Test

TRPC6 Gene Focal segmental glomerulosclerosis type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect mutations in the TRPC6 gene for the diagnosis of Focal Segmental Glomerulosclerosis Type 2 (FSGS2), aiding in early diagnosis, management, and genetic counseling.

Test Code
5388
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with FSGS2.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or using an FTA card for one drop of blood.

Step 3

Report Delivery

Sample is processed for DNA extraction and NGS analysis in the laboratory.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment are required before sample collection.
2
During the Test:A blood sample is drawn from the patient for DNA extraction and NGS analysis.
3
After the Test:The sample is analyzed in the laboratory, and a detailed report is generated within 3 to 4 weeks.

About This Test

Who Should Get This Test

To detect mutations in the TRPC6 gene for the diagnosis of Focal Segmental Glomerulosclerosis Type 2 (FSGS2), aiding in early diagnosis, management, and genetic counseling.

How to Prepare

  • Provide detailed clinical history of the patient.
  • Undergo genetic counseling to assess family history and draw a pedigree chart.
  • Ensure proper sample labeling and handling to avoid contamination.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for TRPC6 mutations is crucial for early diagnosis and management of Focal Segmental Glomerulosclerosis Type 2, helping to prevent kidney failure."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA Card

Sample Stability

Blood samples: Stable at room temperature for 24 hours; refrigerate for longer storage.
FTA cards: Stable at room temperature for extended periods.
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Incorrectly labeled samples

Understanding Your Results

Results from the TRPC6 Gene FSGS2 NGS Genetic Test indicate the presence or absence of mutations in the TRPC6 gene. A positive result confirms a genetic diagnosis of FSGS2, while a negative result suggests no detectable mutations, though clinical correlation is advised.
📊

Positive for TRPC6 mutation

Confirms diagnosis of Focal Segmental Glomerulosclerosis Type 2. Genetic counseling and nephrology referral recommended.

📊

Negative for TRPC6 mutation

No pathogenic mutation detected in the TRPC6 gene. Clinical evaluation for other causes of FSGS may be needed.

📊

Variant of uncertain significance (VUS)

A genetic variant was found but its clinical significance is unknown. Further testing and family studies may be required.

⚠️ When to Consult a Doctor:

If you experience symptoms such as persistent proteinuria, edema, high blood pressure, or have a family history of kidney disease, consult a nephrologist or geneticist for evaluation and possible genetic testing.

Limitations

  • ⚠This test only detects mutations in the TRPC6 gene; other genetic causes of FSGS may not be identified.
  • ⚠Results should be correlated with clinical findings and family history.

Risks & Considerations

  • ●Minimal risks associated with blood draw, such as bruising or infection at the puncture site.
  • ●No significant risks from the genetic test itself.

Interfering Factors

  • ●Contaminated or degraded DNA samples
  • ●Incorrect sample collection or handling

Frequently Asked Questions

What is the TRPC6 Gene FSGS2 NGS Genetic Test?
It is a Next-Generation Sequencing (NGS) test that detects mutations in the TRPC6 gene, which cause Focal Segmental Glomerulosclerosis Type 2 (FSGS2), a rare genetic kidney disorder.
What are the symptoms of FSGS2?
Symptoms include proteinuria, edema, high blood pressure, reduced urine output, weight gain, fatigue, loss of appetite, nausea, vomiting, and itching. Not all individuals may have symptoms.
How is FSGS2 diagnosed?
Diagnosis involves medical history, physical examination, blood and urine tests, and definitive genetic testing like the TRPC6 Gene FSGS2 NGS Genetic Test.
What is the cost of the TRPC6 Gene FSGS2 NGS Genetic Test in India?
The cost is approximately INR 20000, with free home sample collection available across India.
Is the test covered by insurance?
This test may not be covered by insurance and could be an out-of-pocket expense. Check with your insurance provider for details.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
What should I do before getting tested?
Before testing, provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.
What does a positive test result mean?
A positive result confirms a mutation in the TRPC6 gene, indicating a diagnosis of FSGS2. Genetic counseling and nephrology referral are recommended.
What if the test result is negative?
A negative result means no pathogenic mutation was detected in the TRPC6 gene. Clinical evaluation for other causes of kidney disease may be needed.
Can this test be used for family planning?
Yes, genetic testing can help identify carriers and inform family planning decisions through genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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