TTR Gene Amyloidosis NGS Genetic Test
Short Name: TTR Amyloidosis NGS
Also known as: Transthyretin Gene Amyloidosis NGS, ATTR Amyloidosis Genetic Test, Hereditary ATTR Genetic Test
TTR Gene Amyloidosis NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The clinical report and raw data files (FASTQ, VCF) are provided within 3 to 4 weeks of sample receipt at the lab.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the TTR Gene Amyloidosis NGS Genetic Test is to identify disease-causing mutations in the TTR gene. This assists in confirming the diagnosis of hereditary ATTR amyloidosis, enabling early treatment, prognosis determination, and genetic counselling for at-risk family members.
- Test Code
- 3870
- ICD Code
- E85.1
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The clinical report and raw data files (FASTQ, VCF) are provided within 3 to 4 weeks of sample receipt at the lab.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. Inform your doctor about all medications and supplements you are taking. A genetic counselling session is recommended before testing to discuss implications. Bring any previous medical records and a family pedigree chart if available.
Method: Peripheral blood draw or FTA card spot
Laboratory Analysis
A trained phlebotomist will collect a blood sample from your arm, or a blood spot on an FTA card. The procedure is routine and takes about 10 minutes.
Report Delivery
There are no specific precautions after sample collection. You may resume normal activities immediately. The sample will be securely shipped to the laboratory for analysis.
Timeline: The clinical report and raw data files (FASTQ, VCF) are provided within 3 to 4 weeks of sample receipt at the lab.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the TTR Gene Amyloidosis NGS Genetic Test is to identify disease-causing mutations in the TTR gene. This assists in confirming the diagnosis of hereditary ATTR amyloidosis, enabling early treatment, prognosis determination, and genetic counselling for at-risk family members.
How to Prepare
- No fasting is required
- Inform the lab if you have had a blood transfusion or bone marrow transplant in the last 3 months
- Provide a clear clinical history with symptoms and age of onset
- Complete the genetic counselling session to draw a pedigree chart
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"TTR gene amyloidosis can present with varied symptoms. Genetic testing is crucial for family screening and early intervention."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted or underfilled specimen
- Incorrectly labeled sample
- Sample without appropriate clinical history or requisition form
Understanding Your Results
Pathogenic variant detected
Confirms the diagnosis of hereditary TTR gene amyloidosis. Predictive testing for at-risk family members is strongly recommended. Early treatment options can be discussed with a specialist.
Variant of uncertain significance (VUS)
A genetic variant was found but its disease association is unclear. Additional familial testing and segregation analysis are required to clarify its clinical significance.
No pathogenic variant detected
No causative mutation was identified in the TTR gene. If clinical suspicion remains high, consider alternative genetic causes or non-genetic workup.
Consult a neurologist, cardiologist, or clinical geneticist if you experience persistent numbness, weakness, heart rhythm abnormalities, unexplained weight loss, or if you have a family history of TTR amyloidosis. Genetic testing should be performed after appropriate counselling.
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Psychological impact from receiving genetic results
- ●Discovery of unexpected or secondary findings (though not intentionally analyzed)
Interfering Factors
- ●Sample contamination with maternal DNA in prenatal samples
- ●Insufficient DNA quantity
- ●DNA degradation due to improper storage
- ●Recent bone marrow transplantation can influence results in blood-based DNA
Compare With Similar Tests
| Test | TTR Gene Amyloidosis NGS Genetic Test | TTR Gene NGS Test | TTR Gene Sanger Sequencing | Serum Transthyretin Level | Fat Pad Biopsy |
|---|---|---|---|---|---|
| Comparison | TTR Gene Amyloidosis NGS Genetic Test |
Frequently Asked Questions
What is TTR gene amyloidosis?
What is the cost of the TTR gene amyloidosis NGS test at DNA Labs India?
What is the turnaround time for this genetic test?
Which sample is required for the TTR gene amyloidosis NGS test?
Do I need to fast before the test?
Is home sample collection available?
Will the test be covered by insurance?
What do the results mean if a pathogenic variant is found?
Can the test be done for asymptomatic family members?
Are there any risks involved in genetic testing?
Why does DNA Labs India provide raw data, FASTQ, and VCF files?
What is the difference between NGS and Sanger sequencing for TTR gene?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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