U1RNP Antibodies Test
Short Name: U1RNP Antibodies
Also known as: Anti-U1RNP Antibody Test, U1 Ribonucleoprotein Antibody Test, RNP Antibody Test
U1RNP Antibodies Test test available at DNA Labs India for ₹1,989. Uses Enzyme Immunoassay (EIA) on Serum samples. Results in For samples submitted by 9 am on Tuesday or Friday, reports are delivered the same day via email, WhatsApp, or the online portal.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of the U1RNP antibodies test is to detect antibodies directed against the U1 ribonucleoprotein. A positive result supports the clinical diagnosis of mixed connective tissue disease, and in combination with Smith antibodies, provides additional support for systemic lupus erythematosus.
- Test Code
- 3719
- Price
- ₹1,989
- Sample Type
- Serum
- Result Time
- For samples submitted by 9 am on Tuesday or Friday, reports are delivered the same day via email, WhatsApp, or the online portal.
- Fasting Required
- Yes (8 hours)
- Method
- Enzyme Immunoassay (EIA)
Sample Collection
Overnight fasting is preferred. Inform your doctor about any medications and existing health conditions. Wear comfortable clothing to allow easy access to the arm.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will draw blood from a vein in your arm. The procedure takes only a few minutes. If you feel dizzy, inform the staff.
Report Delivery
You can leave immediately after the blood draw and resume regular activities. Keep the pressure bandage on for a few minutes to reduce bruising. If you were fasting, you may eat normally.
Timeline: For samples submitted by 9 am on Tuesday or Friday, reports are delivered the same day via email, WhatsApp, or the online portal.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the U1RNP antibodies test is to detect antibodies directed against the U1 ribonucleoprotein. A positive result supports the clinical diagnosis of mixed connective tissue disease, and in combination with Smith antibodies, provides additional support for systemic lupus erythematosus.
How to Prepare
- Overnight fasting is preferred before sample collection.
- Please inform the lab if you are taking any medications.
- The serum should be separated and transported refrigerated or frozen.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"U1RNP antibodies are most meaningful when interpreted with clinical symptoms, ANA positivity, and the relevant antibody profile including anti-Smith antibodies. A positive result is a strong clue to mixed connective tissue disease when the clinical picture matches."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Grossly hemolytic, lipemic, or icteric sample
- Sample received after 6 hours at room temperature
- Improperly labelled sample
- Sample stored beyond the recommended stability limits
Understanding Your Results
U1RNP antibodies not detected. A negative result does not exclude autoimmune disease.
U1RNP antibodies detected. May support mixed connective tissue disease or SLE when combined with clinical history and other autoantibody results.
Supports diagnosis of mixed connective tissue disease if the patient has relevant clinical symptoms and typical ANA pattern.
Provides additional support for the diagnosis of systemic lupus erythematosus.
If the test is positive or you have symptoms such as persistent fever, rash, joint pain, edema, or difficulty swallowing or breathing, consult a rheumatologist or allergy/immunology specialist for further evaluation.
Limitations
- ⚠A negative result does not exclude autoimmune disease.
- ⚠A positive U1RNP antibody alone is not diagnostic.
- ⚠Results should be interpreted along with clinical features, ANA, anti-Smith, and other autoimmune markers.
Risks & Considerations
- ●Slight pain or bruising at the venipuncture site
- ●Dizziness or lightheadedness during or after blood draw
- ●Rare risk of infection at the collection site
Interfering Factors
- ●Gross haemolysis or lipaemia may interfere with the immunoassay
- ●Sample stored beyond recommended time may affect antibody detection
- ●Recent immunosuppressive therapy may lower antibody levels and can cause false-negative results
Frequently Asked Questions
What is the U1RNP antibodies test?
How much does the U1RNP antibodies test cost at DNA Labs India?
Why is the U1RNP antibodies test done?
Do I need to fast before this test?
What sample is needed for the test?
How will I get my report?
Can this test confirm mixed connective tissue disease?
Can this test diagnose SLE?
What is the reference range for U1RNP antibodies?
Are there any risks in this test?
Where can I get this test done with home collection?
What should I do if my result is positive?
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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