Vasoactive Intestinal Polypeptide VIP Test
Short Name: VIP Test
Also known as: VIP, VIP Assay, Vasoactive Intestinal Peptide Test
Vasoactive Intestinal Polypeptide VIP Test test available at DNA Labs India for ₹22,000. Uses Radioimmunoassay (RIA) on Plasma samples. Results in Samples are collected until the 7th of each month; the report is issued after 2–3 weeks.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of the VIP test is to measure the concentration of vasoactive intestinal polypeptide in the blood. It is used to support the diagnosis of VIPoma and other VIP-secreting neuroendocrine tumors, particularly when a patient has chronic secretory diarrhea, flushing, hypokalemia, and unexplained weight loss.
- Test Code
- 3729
- Price
- ₹22,000
- Sample Type
- Plasma
- Result Time
- Samples are collected until the 7th of each month; the report is issued after 2–3 weeks.
- Fasting Required
- No
- Method
- Radioimmunoassay (RIA)
Sample Collection
No special preparation such as fasting is required. A duly filled Test Send Out Consent Form (Form 35) is mandatory. Inform your doctor about all medicines and supplements you are taking.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect 3 mL of blood in a Lavender Top (EDTA) tube. Plasma must be separated within 2 hours of collection.
Report Delivery
You may resume normal activities immediately. The separated plasma is placed in a plastic transport vial and frozen immediately. The sample must be shipped frozen and must not be thawed during transport.
Timeline: Samples are collected until the 7th of each month; the report is issued after 2–3 weeks.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the VIP test is to measure the concentration of vasoactive intestinal polypeptide in the blood. It is used to support the diagnosis of VIPoma and other VIP-secreting neuroendocrine tumors, particularly when a patient has chronic secretory diarrhea, flushing, hypokalemia, and unexplained weight loss.
How to Prepare
- 3 mL (1.5 mL min.) plasma from 1 Lavender Top (EDTA) tube
- Separate plasma within 2 hours of collection
- Place plasma in a plastic transport vial and freeze immediately
- Ship frozen; DO NOT THAW
- Duly filled Test Send Out Consent Form (Form 35) is mandatory
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"Elevated VIP levels in the setting of secretory diarrhea strongly suggest a VIP-secreting neuroendocrine tumor; however, the diagnosis requires imaging and clinical correlation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Thawed specimen
- EDTA plasma not separated within 2 hours
- Improperly labelled sample
- Missing Test Send Out Consent Form (Form 35)
- Hemolyzed sample
Understanding Your Results
<75 pg/mL
Within the expected reference range. VIPoma is unlikely, but clinical correlation is still required.
75-200 pg/mL
Borderline elevation. Repeat testing and clinical correlation may be needed.
>200 pg/mL
Markedly elevated. Strongly supportive of VIPoma or another VIP-secreting neuroendocrine tumor; imaging localisation is required.
If you have chronic large-volume watery diarrhea, flushing, frequent abdominal pain, unexplained weight loss, or symptoms of electrolyte imbalance such as weakness, fatigue, or muscle cramps, consult a gastroenterologist or endocrinologist.
Limitations
- ⚠Elevated VIP is not specific for VIPoma; other neuroendocrine tumors may also raise VIP levels
- ⚠Normal VIP does not completely exclude the diagnosis if clinical suspicion is high
- ⚠VIP secretion may be intermittent, so repeat testing may be needed
- ⚠Reference ranges vary by laboratory; results should be interpreted by a clinician
Risks & Considerations
- ●Slight pain or bruising at the needle site
- ●Dizziness or lightheadedness during blood draw
- ●Rare local infection or bleeding
Interfering Factors
- ●Delayed plasma separation beyond 2 hours may falsely decrease VIP due to enzymatic degradation
- ●Repeated freeze-thaw cycles may alter VIP stability
- ●Hemolyzed samples may interfere with RIA
- ●Sample thawed during transport may invalidate the result
- ●Certain medications or concurrent neuroendocrine conditions may affect VIP levels
Compare With Similar Tests
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| Comparison | Vasoactive Intestinal Polypeptide VIP Test |
Frequently Asked Questions
What is the Vasoactive Intestinal Polypeptide (VIP) test?
How much does the VIP test cost at DNA Labs India?
What is VIPoma?
What are the symptoms of VIPoma?
Is fasting required for the VIP test?
What sample is required for the VIP test?
How should the VIP sample be transported?
How long does the VIP test report take?
Can a high VIP level be caused by conditions other than VIPoma?
How is VIPoma diagnosed?
Does DNA Labs India provide home sample collection for this test?
Will insurance cover the VIP test?
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