Warfarin Sensitivity Detection Test
Short Name: Warfarin Sensitivity Test
Also known as: Warfarin Sensitivity Test, Warfarin Pharmacogenomics Test, CYP2C9 / VKORC1 Warfarin Sensitivity Test
Warfarin Sensitivity Detection Test test available at DNA Labs India for ₹19,000. Uses PCR Sequencing on Whole Blood samples. Results in Samples received by 11 am are processed and reports are generally available within 13 days.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
This test detects genetic variants that affect warfarin metabolism and sensitivity. It is used to identify patients who may be at increased risk of bleeding or who may need a lower starting dose of warfarin.
- Test Code
- 3760
- Price
- ₹19,000
- Sample Type
- Whole Blood
- Result Time
- Samples received by 11 am are processed and reports are generally available within 13 days.
- Fasting Required
- No
- Method
- PCR Sequencing
Sample Collection
No special preparation is required. Inform your doctor about all current medicines, especially anticoagulants, and any bleeding symptoms.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect 4 mL of whole blood from a vein in your arm. The procedure takes only a few minutes.
Report Delivery
Apply pressure to the puncture site as directed. You may resume normal activities immediately unless your doctor has advised otherwise.
Timeline: Samples received by 11 am are processed and reports are generally available within 13 days.
Patient Instructions
About This Test
Who Should Get This Test
This test detects genetic variants that affect warfarin metabolism and sensitivity. It is used to identify patients who may be at increased risk of bleeding or who may need a lower starting dose of warfarin.
How to Prepare
- No special preparation or fasting is required.
- Inform your healthcare provider about all current medicines, supplements, and herbal products before the test.
- A blood sample will be collected in a lavender top EDTA tube.
- The sample should be transported refrigerated; do not freeze.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This pharmacogenomic test supports safer, more personalised warfarin dosing, but clinical monitoring with INR remains essential."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Frozen blood sample
- Sample in the wrong type of collection tube
- Inadequate sample volume below 2 mL
- Improperly labelled sample
Understanding Your Results
CYP2C9 reduced-function variant detected
Reduced metabolism of the active warfarin isomer can increase drug exposure, leading to higher bleeding risk. Clinicians may consider a lower initial warfarin dose.
VKORC1 variant associated with decreased expression detected
Decreased vitamin K availability may increase warfarin sensitivity and raise INR above the therapeutic target. Dose adjustment may be required.
Both CYP2C9 and VKORC1 variants detected
The combined effect can result in markedly increased warfarin sensitivity. Individualised dosing and close INR monitoring are strongly recommended.
No clinically significant variant detected
The variants assessed by this test were not found. This does not exclude warfarin sensitivity from other genetic variants or non-genetic causes.
If you are taking warfarin and develop symptoms such as unexplained bruising, blood in urine or stool, bleeding from gums or nose, excessive bleeding from cuts, black or tarry stools, severe headache, dizziness, or shortness of breath, contact your healthcare provider immediately.
Limitations
- ⚠The test detects a defined set of pharmacogenetic variants and may not include all possible genetic determinants of warfarin response.
- ⚠A negative result does not exclude the possibility of warfarin sensitivity.
- ⚠Non-genetic factors including age, body weight, diet, liver function, kidney function, and drug interactions influence warfarin response.
- ⚠This test should not replace INR monitoring and clinical supervision.
Risks & Considerations
- ●Minimal discomfort or bruising at the needle site.
- ●Rarely, lightheadedness or fainting during blood collection.
- ●Very small risk of infection at the puncture site.
Interfering Factors
- ●No food or drug interference is expected for DNA analysis.
- ●Poor sample quality, such as a frozen or clotted sample, may affect DNA extraction and downstream testing.
- ●A recent allogeneic blood transfusion may potentially affect the DNA analysis result from whole blood.
Frequently Asked Questions
What is the Warfarin Sensitivity Detection Test?
How much does the Warfarin Sensitivity Detection Test cost?
Do I need to fast before the test?
What sample is needed for this test?
How long does it take to get the report?
What genes are analyzed in this test?
Who should consider this test?
Can this test replace my regular INR monitoring?
What do the results mean?
Is home sample collection available?
Is this test covered by insurance or government schemes?
Can I stop warfarin if my test shows sensitivity?
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