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WDR35 Gene Cranioectodermal dysplasia type 2 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

WDR35 Gene Cranioectodermal dysplasia type 2 NGS Genetic Test

Short Name: WDR35 CED2 NGS Test

Also known as: CED2, Cranioectodermal dysplasia type 2

WDR35 Gene Cranioectodermal dysplasia type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the WDR35 Gene Cranioectodermal dysplasia type 2 NGS Genetic Test is to diagnose CED2 by detecting pathogenic mutations in the WDR35 gene, enabling early intervention, genetic counseling, and family planning.

Test Code
5735
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Provide clinical history and undergo genetic counseling to draw a pedigree chart.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is drawn by a trained phlebotomist using sterile techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store sample appropriately for transport.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling and provide detailed clinical history. No fasting required.
2
During the Test:Sample collection via blood draw; test performed using NGS technology in a certified lab.
3
After the Test:Results are delivered in 3-4 weeks. Follow up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

The purpose of the WDR35 Gene Cranioectodermal dysplasia type 2 NGS Genetic Test is to diagnose CED2 by detecting pathogenic mutations in the WDR35 gene, enabling early intervention, genetic counseling, and family planning.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Label samples correctly
  • Transport at ambient temperature or as specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early diagnosis through genetic testing is crucial for managing CED2 symptoms, planning care, and providing genetic counseling to families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood: 48 hours at 2-8°C
Extracted DNA: stable for several months at -20°C
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Improper labeling
  • Contaminated sample

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the WDR35 gene. A positive result confirms CED2, while a negative result suggests no detectable mutations, but does not rule out all genetic causes.
Positive: Pathogenic variant detected, consistent with CED2 diagnosis.
Negative: No pathogenic variant detected; consider other genetic tests if symptoms persist.
Variant of uncertain significance: Further testing or family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a geneticist or specialist immediately if the test is positive for management planning. If negative but symptoms persist, discuss further diagnostic options.

Limitations

  • ⚠May not detect all types of mutations (e.g., large deletions)
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results may have variants of uncertain significance

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample handling

Frequently Asked Questions

What is Cranioectodermal dysplasia type 2 (CED2)?
CED2 is a rare genetic disorder affecting bone, skin, and tissue development, caused by mutations in the WDR35 gene.
How is CED2 inherited?
It is inherited in an autosomal recessive pattern, requiring two copies of the mutated gene from both parents.
What are the common symptoms of CED2?
Symptoms include craniofacial abnormalities, finger and toe abnormalities, skeletal issues, developmental delays, and intellectual disability.
How is CED2 diagnosed?
Diagnosis is confirmed through genetic testing, specifically the WDR35 Gene NGS Genetic Test.
What does the WDR35 Gene NGS Genetic Test involve?
It uses Next Generation Sequencing to detect mutations in the WDR35 gene from a blood or DNA sample.
How accurate is the NGS test for CED2?
NGS is highly sensitive and specific, providing accurate detection of mutations in the WDR35 gene.
What is the cost of the test at DNA Labs India?
The test costs INR 20,000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks.
What should I do if the test is positive?
Consult a geneticist or specialist for management planning and genetic counseling.
Is genetic counseling recommended?
Yes, genetic counseling is recommended before and after testing to understand implications and support families.
Does DNA Labs India provide raw data with the report?
Yes, DNA Labs India shares raw data, FASTQ, and VCF files along with the clinical report for transparency.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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