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DNA Labs India

WDR36 Gene Glaucoma, Open Angle Type 1G NGS Genetic Test

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WDR36 Gene Glaucoma, Open Angle Type 1G NGS Genetic Test

Short Name: WDR36 Glaucoma NGS Test

Also known as: WDR36 Gene Sequencing, Glaucoma Open Angle Type 1G Genetic Test, POAG1G NGS Test, WDR36 Mutation Analysis

WDR36 Gene Glaucoma, Open Angle Type 1G NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Samples are processed after receipt and reports are delivered within 3 to 4 weeks.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect sequence variants in the WDR36 gene that are associated with primary open-angle glaucoma type 1G. Testing may help confirm a genetic contribution in patients with clinically diagnosed open-angle glaucoma, identify presymptomatic at-risk family members, and guide early monitoring and treatment decisions.

Test Code
3834
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Samples are processed after receipt and reports are delivered within 3 to 4 weeks.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. Clinical history and a genetic counselling session are recommended before giving the sample. Continue all medications unless instructed otherwise by your doctor.

Method: Venipuncture / Finger-prick FTA card / Pre-extracted DNA

Step 2

Laboratory Analysis

Blood is drawn by a trained phlebotomist using a sterile needle. If using an FTA card, a simple finger-prick blood spot is applied to the labelled card.

Step 3

Report Delivery

The sample is sent to the DNA Labs India laboratory. Reports are shared via portal, email and WhatsApp in 3 to 4 weeks. A genetic counsellor is available if you need help understanding your result.

Timeline: Samples are processed after receipt and reports are delivered within 3 to 4 weeks.

Patient Instructions

1
Before the Test:No fasting required. A genetic counselling session is recommended before the test. Please carry the doctor's prescription and family history details.
2
During the Test:The test begins with sample collection. For a blood draw, only a few millilitres are needed. For FTA cards, a finger-prick blood spot is collected.
3
After the Test:Once the sample reaches the laboratory, the NGS sequence analysis is performed. You will receive your report through email, WhatsApp and the online portal after 3 to 4 weeks.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect sequence variants in the WDR36 gene that are associated with primary open-angle glaucoma type 1G. Testing may help confirm a genetic contribution in patients with clinically diagnosed open-angle glaucoma, identify presymptomatic at-risk family members, and guide early monitoring and treatment decisions.

How to Prepare

  • No special preparation or fasting is required.
  • Use an EDTA tube for venous blood; minimum 2 mL is recommended.
  • For FTA card, apply one drop of blood to each marked circle and air-dry.
  • If providing extracted DNA, use a DNase-free tube and send in cold storage.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for WDR36 variants is most useful when combined with a detailed eye examination and genetic counselling. A positive result should prompt regular intraocular pressure checks and optic nerve evaluation in the patient and at-risk relatives."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per collection kit instructions; usually 2 mL EDTA blood or 1-2 FTA spots
ContainerEDTA vacutainer / FTA card / sterile DNA vial
Collection MethodVenipuncture / Finger-prick FTA card / Pre-extracted DNA

Sample Stability

Whole blood in EDTA: stable for up to 48 hours at room temperature.
Extracted DNA: stable at 2-8°C for short transit, long-term at -20°C.
FTA card: stable at ambient temperature for several weeks.
Sample Rejection Criteria:
  • Clotted blood sample in EDTA tube.
  • Insufficient blood volume or DNA quantity.
  • Incorrectly labelled sample or missing patient details.
  • Wet, stained, or contaminated FTA card.
  • Sample container broken during transport.

Understanding Your Results

WDR36 NGS test results are reported as positive, negative, or variant of uncertain significance. The interpretation is based on ACMG/AMP guidelines and must be considered with family history and clinical ophthalmological findings.
📊

Positive / Pathogenic variant

A disease-associated variant was detected. The patient has an increased susceptibility to open-angle glaucoma type 1G. Closer ophthalmological monitoring is recommended.

📊

Positive / Likely pathogenic variant

A variant likely to be disease-causing was detected. Clinical segregation and family correlation are required.

📊

Negative

No pathogenic/likely pathogenic variant was found in WDR36. A hereditary cause in this gene is less likely; other genes or causes may be considered.

📊

Variant of uncertain significance (VUS)

A genetic variant of uncertain clinical significance was found. It cannot be classified as pathogenic or benign based on current evidence. Further family studies may help.

📊

Inconclusive

DNA analysis did not achieve adequate quality or coverage; repeat testing or a new sample may be necessary.

⚠️ When to Consult a Doctor:

If you have a positive or uncertain result, consult an ophthalmologist and a clinical geneticist. Any symptoms such as gradual vision loss, tunnel vision, halos, or eye pain require prompt medical evaluation.

Limitations

  • ⚠WDR36 variants have variable penetrance and are not fully causative; the result improves risk assessment but does not diagnose glaucoma by itself.
  • ⚠A negative WDR36 test does not exclude mutations in other glaucoma genes or non-genetic causes.
  • ⚠Variants of uncertain significance may lack definitive clinical actionability.
  • ⚠Results should always be interpreted by a clinical geneticist in the context of family history and ophthalmological evaluation.

Risks & Considerations

  • ●Minor bruising or pain at the blood collection site.
  • ●Possible psychological stress from genetic findings.
  • ●Implications for blood relatives that may require discussion.
  • ●No significant other physical risks from sample collection.

Interfering Factors

  • ●Variants in non-coding, deep intronic or regulatory regions may not be covered by this targeted test.
  • ●Large genomic deletions, duplications or structural variants may not be detected by standard NGS.
  • ●Low-level mosaic variants below the sensitivity of the assay may be missed.
  • ●Poor DNA quality or sample degradation due to improper transport may affect results.

Compare With Similar Tests

TestWDR36 Gene Glaucoma, Open Angle Type 1G NGS Genetic Test
ComparisonWDR36 Gene Glaucoma, Open Angle Type 1G NGS Genetic Test

Frequently Asked Questions

What is WDR36 gene glaucoma?
WDR36-related open-angle glaucoma is a form of primary open-angle glaucoma, called type 1G. Variants in the WDR36 gene may increase risk of optic nerve damage and require regular eye examinations.
What is the cost of this NGS genetic test at DNA Labs India?
The WDR36 gene glaucoma open angle type 1G NGS genetic test costs INR 20,000. This includes clinical report and raw data files, plus free home collection in select cities.
What sample is required?
Blood (EDTA), extracted DNA, or one drop of blood on an FTA card can be submitted. The lab accepts all three as sample types.
Is fasting needed before the test?
No, fasting is not required for this genetic test. You can eat and drink normally unless your doctor has advised otherwise.
Who should consider this test?
It is advisable for individuals with open-angle glaucoma, early-onset glaucoma, or family history of glaucoma type 1G. It may also be useful for reproductive genetic counselling.
Will I receive raw data?
Yes. DNA Labs India provides FASTQ and VCF files along with the clinical report, which is unique and transparent.
How long does the test report take?
Reports are generally issued within 3 to 4 weeks after the sample reaches the laboratory.
Does this test detect all glaucoma gene mutations?
No, this targeted test only sequences the WDR36 gene. It cannot rule out mutations in other glaucoma-associated genes like MYOC, OPTN, or CYP1B1.
What do negative test results mean?
A negative result means no pathogenic/likely pathogenic WDR36 variant was found. It does not completely exclude genetic or non-genetic glaucoma causes.
Is home sample collection available?
Yes, free home sample collection is available for online bookings in multiple cities across India. Check serviceability at the time of booking.
Is genetic counselling recommended?
Yes. A genetic counselling session is recommended before and after testing to understand family pedigree, inheritance, and clinical implications.
Is the test covered by insurance or government schemes?
Coverage depends on your insurance policy or scheme. DNA Labs India can provide the necessary documentation, but you should check with your insurer.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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