WFS1 Gene Deafness, autosomal dominant type 6 NGS Genetic Test
Short Name: WFS1 Gene Deafness Test
Also known as: DFNA6, WFS1-related deafness, Autosomal dominant deafness 6
WFS1 Gene Deafness, autosomal dominant type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify genetic mutations in the WFS1 gene that cause autosomal dominant type 6 deafness, aiding in diagnosis, management, genetic counseling, and family planning.
- Test Code
- 2319
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- NGS (Next-Generation Sequencing)
Sample Collection
No special preparation required. Ensure the patient is relaxed and provides informed consent. A genetic counseling session is recommended prior to testing.
Method: Venipuncture or finger-prick for FTA card
Laboratory Analysis
For blood sample: venipuncture performed by a trained phlebotomist using sterile techniques. For FTA card: one drop of blood from a finger-prick is applied to the card.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Store the sample as per instructions and transport to the lab promptly.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify genetic mutations in the WFS1 gene that cause autosomal dominant type 6 deafness, aiding in diagnosis, management, genetic counseling, and family planning.
How to Prepare
- Avoid hemolysis by gentle handling of blood sample
- Label sample correctly with patient details
- Ensure FTA card is fully dried before transport
- Maintain sample at ambient room temperature during transit
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for WFS1 mutations can guide management, genetic counseling, and family planning for individuals with hearing loss."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed blood sample
- Incorrect labeling or missing information
- Insufficient sample volume for analysis
- Contaminated or degraded sample
- FTA card with blood spots that are not fully dried
Understanding Your Results
Negative
No pathogenic mutations detected in the WFS1 gene. Hearing loss may be due to other genetic or non-genetic factors.
Positive
Pathogenic mutation identified in the WFS1 gene, confirming autosomal dominant deafness type 6. Genetic counseling and management planning recommended.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is unknown. Further testing, family studies, or clinical correlation may be needed.
Consult a geneticist or audiologist if results are positive or uncertain, or if you have symptoms of hearing loss. Early intervention can improve outcomes through hearing aids, therapy, or other treatments.
Limitations
- ⚠May not detect all types of mutations in WFS1 gene, such as large deletions or rearrangements
- ⚠Variants of uncertain significance (VUS) may be reported, requiring further evaluation
- ⚠Does not replace comprehensive clinical evaluation by a healthcare provider
- ⚠Results are specific to WFS1 gene and may not cover other causes of deafness
Risks & Considerations
- ●Minimal risk from blood draw, such as slight bruising or discomfort
- ●Psychological impact from results, such as anxiety or emotional distress
- ●No significant physical risks from the test itself
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Insufficient sample volume
- ●Technical errors during sequencing
- ●Sample mishandling or delay in transport
Compare With Similar Tests
| Test | WFS1 Gene Deafness, autosomal dominant type 6 NGS Genetic Test | GJB2 Gene Deafness Test | SLC26A4 Gene Test | Comprehensive Deafness Gene Panel | OtoSeq Deafness Gene Panel |
|---|---|---|---|---|---|
| Comparison | WFS1 Gene Deafness, autosomal dominant type 6 NGS Genetic Test |
Frequently Asked Questions
What is WFS1 Gene Deafness?
What are the symptoms of autosomal dominant type 6 deafness?
How is the WFS1 Gene Deafness test performed?
What is the cost of the test?
Is home sample collection available?
How long does it take to get results?
What does a positive result mean?
Can the test detect all mutations in the WFS1 gene?
Is genetic counseling provided with the test?
Who should consider getting tested?
What is the difference between NGS and other genetic tests?
Are there any risks to the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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