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DNA Labs India

Wilson Disease Panel Test

DNA Labs India | ISO 9001:2015 Certified

Wilson Disease Panel Test

Short Name: Wilson Panel

Also known as: Wilson Disease Profile, Copper Metabolism Panel, Wilson Disease Evaluation

Wilson Disease Panel Test test available at DNA Labs India for ₹5,500. Uses Spectrophotometry, Nephelometry, Electrical Impedence, VCS, ICPMS on Blood and Urine samples. Results in Samples received Monday to Saturday by 6 pm are reported the next day.. Free home collection in 300+ cities across India.

Copper Metabolism ProfileAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Ramarao Paidisetty

Dr Ramarao Paidisetty

Consultant Biochemist · Reg: 21504

Last reviewed: September 7, 2026

Overview

The purpose of the Wilson Disease Panel Test is to evaluate copper metabolism and detect liver involvement. It combines markers used in the workup of Wilson disease and helps differentiate it from other liver or neurological conditions. The panel supports clinicians in confirming a suspected diagnosis and in screening family members who may share the genetic risk.

Test Code
3761
ICD Code
E83.01
Price
₹5,500
Sample Type
Blood and Urine
Result Time
Samples received Monday to Saturday by 6 pm are reported the next day.
Fasting Required
No
Method
Spectrophotometry, Nephelometry, Electrical Impedence, VCS, ICPMS
Step 1

Sample Collection

No fasting is required. If barium-containing contrast media has been administered, the specimen should not be collected for 96 hours. Inform your doctor about any supplements containing copper.

Method: Venipuncture and 24-hour urine collection

Step 2

Laboratory Analysis

Blood will be drawn in multiple tubes. A 24-hour urine collection container will be provided. Follow the instructions given by the collection team carefully.

Step 3

Report Delivery

Keep the urine collection container refrigerated during the collection period. Ship all specimens refrigerated. Do not freeze specimens. Resume normal activities after blood collection.

Timeline: Samples received Monday to Saturday by 6 pm are reported the next day.

Patient Instructions

1
Before the Test:No fasting is required. If barium-containing contrast media has been administered, wait for 96 hours before giving the sample.
2
During the Test:Blood will be drawn in multiple tubes and a 24-hour urine collection container will be provided. Instructions will be given by the collection team.
3
After the Test:You may resume normal activities. Ensure the urine sample is stored in the refrigerator during collection. Do not freeze.

About This Test

Who Should Get This Test

The purpose of the Wilson Disease Panel Test is to evaluate copper metabolism and detect liver involvement. It combines markers used in the workup of Wilson disease and helps differentiate it from other liver or neurological conditions. The panel supports clinicians in confirming a suspected diagnosis and in screening family members who may share the genetic risk.

How to Prepare

  • Collect 3 mL whole blood in lavender top EDTA tube
  • Collect 2 mL serum in SST
  • Collect 3 mL serum in metal-free white top tube
  • Collect 24-hour urine in an acid-washed metal-free container; send 10 mL aliquot
  • Use powderless gloves during specimen collection
  • Do not freeze specimens

Doctor's Notes

Reviewed by — MBBS, MD (Biochemistry) · Reg. No. 21504

"Biochemical copper markers rarely make sense in isolation. The full pattern, together with liver function and clinical findings, is what helps a geneticist or hepatologist interpret the disorder correctly."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood and Urine
Sample VolumeBlood: 3 mL EDTA whole blood, 2 mL serum SST, 3 mL serum metal-free white top; Urine: 10 mL aliquot from 24-hour collection
ContainerLavender Top (EDTA), SST, Metal-free White Top, 24-hour Urine Container
Collection MethodVenipuncture and 24-hour urine collection

Sample Stability

Room Temperature: 8 hours
Refrigerator: 48 hours
Frozen: Not acceptable
Sample Rejection Criteria:
  • Frozen specimen received
  • Specimen collected within 96 hours of barium-containing contrast media
  • Urine collected in a non-acid-washed or non-metal-free container
  • Incomplete 24-hour urine collection
  • Unlabelled, leaking or haemolysed sample

Understanding Your Results

The results of this panel should be interpreted by a clinician, preferably in consultation with a gastroenterologist or clinical geneticist. No single value is diagnostic by itself.
📊

Low serum ceruloplasmin, low serum copper, high 24-hour urine copper

Strongly suggestive of Wilson disease; clinical correlation required.

📊

High 24-hour urine copper with normal serum ceruloplasmin

May occur in Wilson disease but also in chronic active hepatitis or cholestasis; confirm clinically.

📊

Normal serum and urine copper

Wilson disease is less likely, but genetic testing may still be considered if clinical suspicion is high.

📊

Abnormal LFT with low ceruloplasmin

Needs full liver work-up and review by a hepatologist.

⚠️ When to Consult a Doctor:

Consult your doctor if you have unexplained jaundice, fatigue, abdominal pain, tremors, difficulty speaking, or mood changes, especially if there is a family history of Wilson disease.

Limitations

  • ⚠Reference ranges may vary with age, sex and laboratory method.
  • ⚠No single biochemical marker is diagnostic on its own.
  • ⚠Elevated urinary copper can also occur in cholestatic liver diseases.
  • ⚠This panel does not replace liver biopsy when tissue copper quantification is needed.
  • ⚠If ATP7B mutation status is required, molecular genetic testing must be ordered separately.

Risks & Considerations

  • ●Mild pain or bruising at the venipuncture site
  • ●Dizziness or light-headedness during blood collection
  • ●Hematoma
  • ●Infection at the puncture site (very rare)

Interfering Factors

  • ●Barium-containing contrast media administered within 96 hours
  • ●Copper supplement intake
  • ●Specimen contamination from non-metal-free tubes
  • ●Haemolysed blood samples
  • ●Improper urine storage or incomplete 24-hour collection

Compare With Similar Tests

TestWilson Disease Panel Test
ComparisonWilson Disease Panel Test

Frequently Asked Questions

What is the Wilson Disease Panel Test?
It is a group of blood and urine tests that assess copper metabolism and liver function to help diagnose Wilson disease. It includes CBC, LFT, ceruloplasmin, serum copper and 24-hour urine copper.
Why is the Wilson Disease Panel Test done?
It is ordered when Wilson disease is suspected based on symptoms like jaundice, fatigue, tremors, speech difficulty or psychiatric features. It is also useful for screening family members at risk.
What is the price of the Wilson Disease Panel Test?
The test cost is Rs 5500.0 inclusive of home sample collection in most Indian cities.
What samples are required for this test?
3 mL whole blood in EDTA, 2 mL serum in SST, 3 mL serum in a metal-free white top tube, and a 10 mL aliquot from a 24-hour urine collection.
Do I need to fast for the Wilson Disease Panel Test?
No fasting is required. However, if barium-containing contrast media has been administered, the specimen should not be collected for 96 hours.
How long will the report take?
Samples received Monday to Saturday by 6 pm are reported the next day.
Can this test be used for family screening?
Yes. The panel may help identify family members who have abnormal copper metabolism and require formal genetic counselling and further testing.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings for the Wilson Disease Panel Test in more than 200 cities.
What do low ceruloplasmin and high urine copper mean?
This combination is frequently seen in Wilson disease. The final diagnosis must be made by your physician after full clinical assessment.
Does this panel test the ATP7B gene directly?
The biochemical panel evaluates the effects of copper metabolism. If a specific ATP7B mutation must be identified, gene sequencing is a separate molecular test.
Are there any risks involved?
The blood draw has routine risks such as slight pain, bruising or, rarely, infection. There are no special risks from urine collection.
Who can order this test?
A physician, gastroenterologist, or ophthalmologist may order the Wilson Disease Panel Test based on clinical signs, liver abnormalities, or copper metabolism concerns.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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