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WNK4 Gene Pseudohypoaldosteronism, type 2B NGS Genetic Test

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WNK4 Gene Pseudohypoaldosteronism, type 2B NGS Genetic Test

Short Name: WNK4 Gene PHA2B Test

Also known as: Pseudohypoaldosteronism Type IIB, PHA2B, Familial Hyperkalemic Hypertension

WNK4 Gene Pseudohypoaldosteronism, type 2B NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose pseudohypoaldosteronism type 2B by detecting pathogenic mutations in the WNK4 gene using NGS technology, aiding in clinical management and genetic counseling.

Test Code
5497
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No special preparation required. Provide clinical history and undergo genetic counseling to draw a pedigree chart of family members affected.

Method: Venipuncture or Cheek Swab

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture or a cheek swab will be taken. The sample is labeled and sent to the laboratory.

Step 3

Report Delivery

The sample is processed for NGS analysis. Results are reviewed by a geneticist and reported within 3-4 weeks.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling and provide clinical history. No fasting required.
2
During the Test:Sample collection via blood draw or cheek swab, which is quick and minimally invasive.
3
After the Test:Wait for results (3-4 weeks). Discuss findings with a geneticist or physician for next steps.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose pseudohypoaldosteronism type 2B by detecting pathogenic mutations in the WNK4 gene using NGS technology, aiding in clinical management and genetic counseling.

How to Prepare

  • Provide a blood sample or cheek swab
  • Ensure sample is properly labeled with patient details
  • Follow instructions for FTA card if used

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for WNK4 mutations can guide treatment and management of pseudohypoaldosteronism type 2B, helping to prevent complications like hypertension and electrolyte imbalances."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or Cheek Swab

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or contaminated samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the WNK4 gene. A positive result confirms a diagnosis of pseudohypoaldosteronism type 2B, while a negative result suggests no pathogenic variants were detected, but clinical correlation is advised.
Positive: Pathogenic mutation detected, confirming pseudohypoaldosteronism type 2B. Consult a geneticist for management.
Negative: No pathogenic variants detected. Consider other causes if symptoms persist.
Variant of uncertain significance: Further testing or family studies may be recommended.
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms like dehydration, blood pressure abnormalities, or electrolyte imbalances, or if you have a family history of the condition.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Not a substitute for comprehensive clinical evaluation

Risks & Considerations

  • ●Minor discomfort or bruising from blood draw
  • ●Minimal risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Improper sample storage
  • ●Recent blood transfusion

Frequently Asked Questions

What is the WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the WNK4 gene, which cause pseudohypoaldosteronism type 2B, a disorder affecting salt and water balance.
Who should consider getting this test?
Individuals with symptoms like dehydration, blood pressure issues, or electrolyte imbalances, and those with a family history of pseudohypoaldosteronism type 2B.
What are the common symptoms of pseudohypoaldosteronism type 2B?
Symptoms include dehydration, high or low blood pressure, increased thirst, frequent urination, fatigue, muscle weakness, and delayed growth in children.
How is the test performed?
A blood sample or cheek swab is collected and analyzed using NGS technology to identify mutations in the WNK4 gene.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available across India.
Is the test covered by insurance?
Coverage depends on your insurance policy. It is not universally covered, so check with your provider.
How long does it take to get the results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive test result mean?
A positive result confirms a mutation in the WNK4 gene, indicating pseudohypoaldosteronism type 2B. Consult a geneticist for management.
What does a negative test result mean?
A negative result means no pathogenic variants were detected, but clinical correlation is advised if symptoms persist.
Are there any risks associated with the test?
Risks are minimal, such as minor discomfort from blood draw. Genetic results may have psychological implications.
Can the test be done at home?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India.
What should I do after receiving the test results?
Discuss the results with a healthcare professional or geneticist to understand implications and plan treatment or management.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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