WNT10B Gene Split-hand/foot malformation type 6 NGS Genetic Test
Short Name: WNT10B SHFM6 NGS Test
Also known as: WNT10B Gene Mutation Test, SHFM6 Genetic Test, Split-hand/foot malformation type 6 NGS Panel
WNT10B Gene Split-hand/foot malformation type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of this test is to confirm a clinical diagnosis of Split-hand/foot malformation type 6 by identifying pathogenic variants in the WNT10B gene. It is also used for carrier testing in families with a history of SHFM6, prenatal diagnosis in at-risk pregnancies, and to provide prognostic information for affected individuals. Genetic testing helps in understanding the inheritance pattern, enabling informed reproductive decisions and early intervention strategies.
- Test Code
- 5939
- CPT Code
- 81408
- ICD Code
- Q71.6
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before the test to discuss the clinical history and draw a pedigree chart. Please inform the lab about any relevant medical history or family history of limb malformations.
Method: Peripheral blood draw or FTA card spot
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. If using FTA card, a few drops of blood will be placed on the card. The procedure is quick and minimally invasive.
Report Delivery
No specific precautions are needed after sample collection. You can resume normal activities immediately. The sample will be transported to the laboratory for analysis.
Timeline: Reports are typically available within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this test is to confirm a clinical diagnosis of Split-hand/foot malformation type 6 by identifying pathogenic variants in the WNT10B gene. It is also used for carrier testing in families with a history of SHFM6, prenatal diagnosis in at-risk pregnancies, and to provide prognostic information for affected individuals. Genetic testing helps in understanding the inheritance pattern, enabling informed reproductive decisions and early intervention strategies.
How to Prepare
- Ensure the sample is collected in the provided EDTA vacutainer or on the FTA card.
- Label the sample with patient's name, date of birth, and collection date.
- If using FTA card, allow it to air dry completely before placing in the provided envelope.
- Store blood sample at room temperature if shipping within 24 hours; otherwise refrigerate.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for SHFM6 is crucial for accurate diagnosis and family planning. NGS provides comprehensive analysis of the WNT10B gene, enabling early intervention and management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit without proper storage
Understanding Your Results
Positive (Pathogenic variant detected)
Confirms diagnosis of SHFM6. Genetic counseling is recommended for family planning and management.
Negative (No pathogenic variant detected)
Reduces likelihood of WNT10B-related SHFM6, but other genetic causes may still be considered.
Variant of Uncertain Significance (VUS)
Further testing or family studies may be needed to determine clinical significance.
If you or your child have symptoms suggestive of split-hand/foot malformation, or if there is a family history of SHFM6, consult a clinical geneticist or pediatrician for evaluation and genetic testing.
Limitations
- ⚠This test only analyzes the WNT10B gene and does not rule out other genetic causes of SHFM.
- ⚠Variants in non-coding regulatory regions may not be detected.
- ⚠Results should be interpreted in the context of clinical findings and family history.
- ⚠Genetic counseling is recommended to understand the implications of results.
Risks & Considerations
- ●No significant physical risks associated with blood draw.
- ●Possible psychological impact of genetic results.
- ●Risk of incidental findings (unrelated genetic variants).
Interfering Factors
- ●Poor quality or degraded DNA sample
- ●Contamination during sample collection
- ●Incomplete clinical information provided
- ●Presence of large deletions/duplications not detected by standard NGS (may require additional testing)
Compare With Similar Tests
| Test | WNT10B Gene Split-hand/foot malformation type 6 NGS Genetic Test | Chromosomal Microarray (CMA) | Whole Exome Sequencing (WES) | Targeted SHFM Panel |
|---|---|---|---|---|
| Comparison | WNT10B Gene Split-hand/foot malformation type 6 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the WNT10B Gene SHFM6 NGS Genetic Test?
What sample is required for this test?
How long does it take to get results?
Is fasting required before the test?
What does the test detect?
Will I receive raw data files?
Is genetic counseling included?
Can this test be done for prenatal diagnosis?
What is the turnaround time for outstation samples?
Is home sample collection available in my city?
What is the accuracy of NGS for this test?
Can this test detect carriers?
Related Tests
KIAA0586 Gene Joubert syndrome type 23 NGS Genetic Test
₹20,000CAT Gene Acatalasemia NGS Genetic Test
₹20,000BLM Gene Bloom syndrome NGS Genetic Test
₹20,000FANCC Gene Fanconi anemia type C NGS Genetic Test
₹20,000TPI1 Gene Triosephosphate isomerase deficiency NGS Genetic Test
₹20,000PTPN23 Gene Ciliogenesis related disorder NGS Genetic Test
₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.