WRN Gene Werner syndrome NGS Genetic Test
Short Name: WRN NGS Test
Also known as: Werner Syndrome Genetic Test, WRN Gene Sequencing, Premature Aging Genetic Test
WRN Gene Werner syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm or rule out Werner syndrome by identifying mutations in the WRN gene. It aids in differential diagnosis of progeroid syndromes, guides clinical management, and provides information for reproductive planning.
- Test Code
- 5987
- CPT Code
- 81407
- ICD Code
- E34.8
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended to discuss the implications of the test.
Method: Venipuncture or FTA card blood spot
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. For FTA card, a few drops of blood will be placed on the card.
Report Delivery
No restrictions. You can resume normal activities immediately.
Timeline: Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm or rule out Werner syndrome by identifying mutations in the WRN gene. It aids in differential diagnosis of progeroid syndromes, guides clinical management, and provides information for reproductive planning.
How to Prepare
- For blood sample: Use EDTA tube, fill to indicated mark.
- For FTA card: Apply blood drops to the designated circles, allow to air dry.
- Label the sample with patient name, date, and time of collection.
- Transport the sample to the lab at ambient temperature.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Werner syndrome is a rare autosomal recessive disorder. Early diagnosis through NGS can help manage complications and guide family planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improper labeling
- Sample received after prolonged transit without proper storage
Understanding Your Results
Positive (Pathogenic variant detected)
Confirms diagnosis of Werner syndrome. Genetic counseling is recommended for the patient and family members.
Negative (No pathogenic variant detected)
Reduces likelihood of Werner syndrome, but does not exclude it if clinical suspicion is high. Consider other progeroid syndromes.
Variant of Uncertain Significance (VUS)
A variant was found but its clinical significance is unknown. Further testing of family members may help clarify.
Consult a geneticist or your healthcare provider if you have symptoms suggestive of Werner syndrome, a family history of the condition, or if you are planning a family and have concerns about genetic risk.
Limitations
- ⚠This test detects mutations in the coding regions and splice sites of the WRN gene; deep intronic or regulatory region mutations may not be detected.
- ⚠Large deletions/duplications may not be identified by standard NGS; additional testing may be required.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠Negative result does not completely exclude Werner syndrome if clinical suspicion is high; other genetic causes may be considered.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic testing results
- ●Potential for incidental findings
Interfering Factors
- ●Poor DNA quality or quantity from sample
- ●Contamination during sample collection
- ●Recent blood transfusion (may dilute DNA)
- ●Bone marrow transplant (may affect results)
Compare With Similar Tests
| Test | WRN Gene Werner syndrome NGS Genetic Test | WRN Gene Single Gene Sequencing | Progeroid Panel (NGS) | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | WRN Gene Werner syndrome NGS Genetic Test |
Frequently Asked Questions
What is Werner syndrome?
How is Werner syndrome diagnosed?
What is the cost of the WRN gene NGS test in India?
What sample is required for the test?
Do I need to fast before the test?
How long does it take to get results?
Is home sample collection available?
What does the test report include?
Can this test detect all WRN gene mutations?
Who should consider this test?
Is genetic counseling included?
Are there any risks associated with the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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